乳铁蛋白作用于人类单核细胞的Ia样抗原阳性亚群，以在体外抑制集落刺激活性的产生。
Lactoferrin acts on Ia-like antigen-positive subpopulations of human monocytes to inhibit production of colony stimulatory activity in vitro.
作者信息
Broxmeyer H E
出版信息
J Clin Invest. 1979 Dec;64(6):1717-20. doi: 10.1172/JCI109635.
Abstract
The relationship between Ia-like antigens (Ia-antigens) on human monocytes and the ability of lactoferrin (LF) to inhibit the production of colony stimulatory activity (CSA) for granulocyte and macrophage colony formation was investigated. Complement-dependent cytotoxicity of human monocytes by antiserum to Ia-antigen-reduced CSA production by 50%. LF decreased CSA production by monocytes but had no influence on monocytes insensitive to anti-Ia and complement. Anti-Ia in the absence of complement had no effect on production of CSA but blocked the inhibitory action of LF. This suggsts that LF inhibits production of CSA from an Ia-antigen-positive subpopulation of human blood monocytes. This may be of relevance to the regulation of myelopoiesis.
摘要
研究了人类单核细胞上的Ia样抗原（Ia抗原）与乳铁蛋白（LF）抑制粒细胞和巨噬细胞集落形成的集落刺激活性（CSA）产生能力之间的关系。抗Ia抗原血清对人类单核细胞的补体依赖性细胞毒性使CSA产生减少了50%。LF降低了单核细胞的CSA产生，但对不敏感于抗Ia和补体的单核细胞没有影响。在无补体情况下，抗Ia对CSA产生没有影响，但阻断了LF的抑制作用。这表明LF抑制人类血液单核细胞Ia抗原阳性亚群的CSA产生。这可能与骨髓生成的调节有关。
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本文引用的文献
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