Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
J Am Acad Dermatol. 2021 Sep;85(3):665-670. doi: 10.1016/j.jaad.2019.09.015. Epub 2019 Sep 18.
The yield of skin biopsies in the evaluation of intravascular lymphoma (IVL) is largely unknown in Western patients. Most data supporting this test come from Asian populations, in which both prevalence and disease presentation seem to differ.
To determine the yield and diagnostic properties of skin biopsy in the evaluation of IVL.
We reviewed skin biopsy pathology reports of 50 patients being evaluated for IVL to calculate the diagnostic yield of this test. An additional 6 patients, who underwent skin biopsies after the diagnosis of IVL was made by other means, were included to calculate the sensitivity and specificity of our index test.
Skin biopsy samples were positive for 5 of the 50 patients being investigated for IVL. Sensitivity was 50% and specificity was 100%.
Only pathology reports containing IVL as an indication for the biopsy were retrieved. This might have excluded patients in whom the disease was considered but was not deemed likely enough to be listed as the indication for the test, inflating our estimative of skin biopsy yield.
A relatively high diagnostic yield was found in the evaluation of IVL among patients with a diverse presentation in a Western hospital.
在评估血管内淋巴瘤（IVL）时，皮肤活检的检出率在西方患者中尚不清楚。大多数支持该检测的证据来自亚洲人群，其流行率和疾病表现似乎存在差异。
确定皮肤活检在评估 IVL 中的检出率和诊断性能。
我们回顾了 50 例接受 IVL 评估的患者的皮肤活检病理报告，以计算该检测的诊断检出率。还纳入了另外 6 例在其他方法诊断为 IVL 后进行皮肤活检的患者，以计算我们的筛选试验的敏感性和特异性。
在接受 IVL 评估的 50 例患者中，有 5 例皮肤活检样本阳性。敏感性为 50%，特异性为 100%。
仅检索了包含将 IVL 作为活检指征的病理报告。这可能排除了那些被认为患有该疾病但被认为不太可能作为检测指征的患者，从而夸大了我们对皮肤活检检出率的估计。
在一家西方医院中，具有不同临床表现的 IVL 患者中，皮肤活检的诊断检出率相对较高。
