Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
Phys Med. 2019 Oct;66:8-14. doi: 10.1016/j.ejmp.2019.09.072. Epub 2019 Sep 18.
The shift from reactor to accelerator based neutron production has created a renewed interested in Boron Neutron Capture Therapy (BNCT). BNCT is reliant upon the favourable uptake of B by tumour cells along with the interaction with neutrons to produce high LET fragments (He and Li nuclei) that deposit energy locally within the tumour cells. As with any radiation based treatment, Quality Assurance (QA) is crucial. In particular, Geant4 was used to model and optimise the geometry and packaging of Silicon on Insulator (SOI) microdosimeters for BNCT Quality Assurance purposes in view of experimental measurements at the KUR research reactor, in Japan. In this context, design optimisation pertains to the sensitive volume size and probability of neutron activation. This study has shown conclusively that whilst the materials currently used in the fabrication of silicon based microdosimeters are appropriate, there are changes with respect to the sensitive volume thickness that should be addressed to reduce the number of 'stoppers' in the microdosimeter.
从反应堆向基于加速器的中子产生的转变，使人们对硼中子俘获治疗（BNCT）重新产生了兴趣。BNCT依赖于肿瘤细胞对硼的摄取以及与中子的相互作用，以产生高传能线密度碎片（氦和锂原子核），从而在肿瘤细胞内局部沉积能量。与任何基于辐射的治疗一样，质量保证（QA）至关重要。特别是，为了在日本 KUR 研究反应堆进行实验测量，使用 Geant4 对绝缘体上硅（SOI）微剂量计的几何形状和包装进行建模和优化，用于 BNCT 的质量保证目的。在这种情况下，设计优化涉及到灵敏体积大小和中子激活的概率。这项研究已经明确表明，虽然目前用于制造硅基微剂量计的材料是合适的，但在敏感体积厚度方面存在一些需要解决的变化，以减少微剂量计中的“停止器”数量。
