dNTP 代谢物在胚胎细胞周期调控中的作用。
The role of dNTP metabolites in control of the embryonic cell cycle.
机构信息
Institut für Entwicklungsbiochemie, Universitätsmedizin, Georg-August-Universität , Göttingen , Germany.
Entwicklungsgenetik, Fachbereich Biologie, Philipps-Universität , Marburg , Germany.
出版信息
Cell Cycle. 2019 Nov;18(21):2817-2827. doi: 10.1080/15384101.2019.1665948. Epub 2019 Sep 22.
Abstract
Deoxyribonucleotide metabolites (dNTPs) are the substrates for DNA synthesis. It has been proposed that their availability influences the progression of the cell cycle during development and pathological situations such as tumor growth. The mechanism has remained unclear for the link between cell cycle and dNTP levels beyond their role as substrates. Here, we review recent studies concerned with the dynamics of dNTP levels in early embryos and the role of DNA replication checkpoint as a sensor of dNTP levels.
摘要
脱氧核苷酸代谢物 (dNTPs) 是 DNA 合成的底物。据推测，它们的可用性会影响发育过程中和肿瘤生长等病理情况下细胞周期的进程。除了作为底物的作用外，细胞周期与 dNTP 水平之间的联系机制尚不清楚。本文综述了近期关于早期胚胎中 dNTP 水平动态变化以及 DNA 复制检验点作为 dNTP 水平传感器作用的研究。
相似文献
1
The role of dNTP metabolites in control of the embryonic cell cycle.dNTP 代谢物在胚胎细胞周期调控中的作用。
Cell Cycle. 2019 Nov;18(21):2817-2827. doi: 10.1080/15384101.2019.1665948. Epub 2019 Sep 22.
2
A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.脱氧核苷酸代谢物与胚胎细胞周期控制之间的联系。
Curr Biol. 2019 Apr 1;29(7):1187-1192.e3. doi: 10.1016/j.cub.2019.02.021. Epub 2019 Mar 14.
3
Dynamic Control of dNTP Synthesis in Early Embryos.早期胚胎中脱氧核糖核苷酸三磷酸（dNTP）合成的动态调控
Dev Cell. 2017 Aug 7;42(3):301-308.e3. doi: 10.1016/j.devcel.2017.06.013. Epub 2017 Jul 20.
4
Checkpoint deficient rad53-11 yeast cannot accumulate dNTPs in response to DNA damage.检查点缺陷型rad53-11酵母在DNA损伤时无法积累脱氧核苷酸三磷酸。
Biochem Biophys Res Commun. 2007 Feb 9;353(2):527-30. doi: 10.1016/j.bbrc.2006.12.049. Epub 2006 Dec 18.
5
6
dNTP production is essential for normal postnatal murine heart development.dNTP 生成对于正常的产后鼠心脏发育至关重要。
J Biol Chem. 2019 Nov 1;294(44):15889-15897. doi: 10.1074/jbc.RA119.009492. Epub 2019 Jul 12.
7
Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.DNA损伤后及静息细胞中哺乳动物核糖核苷酸还原和脱氧核苷酸三磷酸库的调控
J Biol Chem. 2006 Mar 24;281(12):7834-41. doi: 10.1074/jbc.M512894200. Epub 2006 Jan 24.
8
p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.p21通过减少脱氧核苷三磷酸生物合成和调节SAMHD1抗病毒活性来限制单核细胞衍生树突状细胞中的HIV-1。
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01324-17. Print 2017 Dec 1.
9
Deoxyribonucleotides as genetic and metabolic regulators.脱氧核糖核苷酸作为遗传和代谢调节因子。
FASEB J. 2014 Sep;28(9):3832-40. doi: 10.1096/fj.14-251249. Epub 2014 Jun 13.
10
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.高度诱变和严重失衡的 dNTP 池可以逃避 S 期检查点的检测。
Nucleic Acids Res. 2010 Jul;38(12):3975-83. doi: 10.1093/nar/gkq128. Epub 2010 Mar 9.
引用本文的文献
1
Resolving early embryonic metabolism in Drosophila through single-embryo metabolomics and transcriptomics.通过单胚胎代谢组学和转录组学解析果蝇早期胚胎代谢
Nat Metab. 2025 Aug 13. doi: 10.1038/s42255-025-01351-5.
2
SHMT2 is essential for mammalian preimplantation embryonic development through biosynthesis of nucleotide metabolites.丝氨酸羟甲基转移酶2（SHMT2）通过核苷酸代谢物的生物合成对哺乳动物植入前胚胎发育至关重要。
Mol Ther Nucleic Acids. 2025 Mar 5;36(2):102499. doi: 10.1016/j.omtn.2025.102499. eCollection 2025 Jun 10.
3
DTYMK is an essential gene in mice and heterozygosity does not cause neural tube defects.DTYMK是小鼠中的一个必需基因，杂合性不会导致神经管缺陷。
Arch Biochem Biophys. 2024 May;755:109991. doi: 10.1016/j.abb.2024.109991. Epub 2024 Apr 15.
4
Collective effects of cell cleavage dynamics.细胞分裂动力学的集体效应。
Front Cell Dev Biol. 2024 Mar 15;12:1358971. doi: 10.3389/fcell.2024.1358971. eCollection 2024.
5
MTBSTFA derivatization-LC-MS/MS approach for the quantitative analysis of endogenous nucleotides in human colorectal carcinoma cells.MTBSTFA衍生化-LC-MS/MS法用于人结肠癌细胞内源性核苷酸的定量分析。
J Pharm Anal. 2022 Feb;12(1):77-86. doi: 10.1016/j.jpha.2021.01.001. Epub 2021 Jan 22.
6
Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders.在不同发育阶段的斑马鱼中胸苷酸生物合成酶的差异表达：对 dtymk 突变引起的神经退行性疾病的影响。
BMC Neurosci. 2022 Mar 27;23(1):19. doi: 10.1186/s12868-022-00704-0.
7
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.lncRNA IGF2-AS 通过介导 HMGA1 调节核苷酸代谢促进脓毒症患者内皮祖细胞发生细胞焦亡
Oxid Med Cell Longev. 2022 Jan 17;2022:9369035. doi: 10.1155/2022/9369035. eCollection 2022.
8
dNTPpoolDB: a manually curated database of experimentally determined dNTP pools and pool changes in biological samples.dNTP 池数据库：一个经过人工整理的实验确定的 dNTP 池和生物样本中池变化的数据库。
Nucleic Acids Res. 2022 Jan 7;50(D1):D1508-D1514. doi: 10.1093/nar/gkab910.
9
Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells.羟基喜树碱通过干扰人结直肠癌细胞核苷酸代谢发挥抗肿瘤作用。
Molecules. 2021 Aug 13;26(16):4902. doi: 10.3390/molecules26164902.
10
Temporal Gradients Controlling Embryonic Cell Cycle.控制胚胎细胞周期的时间梯度
Biology (Basel). 2021 Jun 9;10(6):513. doi: 10.3390/biology10060513.
本文引用的文献
1
Quantitative solid-phase assay to measure deoxynucleoside triphosphate pools.用于测量脱氧核苷三磷酸池的定量固相分析。
Biol Methods Protoc. 2018 Oct 11;3(1):bpy011. doi: 10.1093/biomethods/bpy011. eCollection 2018.
2
Genome wide decrease of DNA replication eye density at the midblastula transition of .合子基因组激活期. 中 DNA 复制眼密度的全基因组减少。
Cell Cycle. 2019 Jul;18(13):1458-1472. doi: 10.1080/15384101.2019.1618641. Epub 2019 May 26.
3
A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.脱氧核苷酸代谢物与胚胎细胞周期控制之间的联系。
Curr Biol. 2019 Apr 1;29(7):1187-1192.e3. doi: 10.1016/j.cub.2019.02.021. Epub 2019 Mar 14.
4
Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.发育细胞周期和合子转录的代谢调控。
Curr Biol. 2019 Apr 1;29(7):1193-1198.e5. doi: 10.1016/j.cub.2019.02.028. Epub 2019 Mar 14.
5
High speed of fork progression induces DNA replication stress and genomic instability.叉突高速推进诱导 DNA 复制应激和基因组不稳定性。
Nature. 2018 Jul;559(7713):279-284. doi: 10.1038/s41586-018-0261-5. Epub 2018 Jun 27.
6
Modified nucleoside triphosphates exist in mammals.修饰的核苷三磷酸存在于哺乳动物中。
Chem Sci. 2018 Apr 2;9(17):4160-4167. doi: 10.1039/c7sc05472f. eCollection 2018 May 7.
7
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.人类 SHMT 抑制剂揭示了缺陷性甘氨酸摄取是弥漫性大 B 细胞淋巴瘤可靶向的代谢脆弱性。
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9.
8
Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.组蛋白甲基转移酶 Set2 通过 MBF 依赖性转录促进 DNA 复制和诱导遗传毒性应激反应。
Cell Rep. 2017 Sep 12;20(11):2693-2705. doi: 10.1016/j.celrep.2017.08.058.
9
Dynamic Control of dNTP Synthesis in Early Embryos.早期胚胎中脱氧核糖核苷酸三磷酸（dNTP）合成的动态调控
Dev Cell. 2017 Aug 7;42(3):301-308.e3. doi: 10.1016/j.devcel.2017.06.013. Epub 2017 Jul 20.
10
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.缺乏 dNTP 会导致 APC/C 辅助因子 Cdh1 缺失时复制动态和 DNA 断裂的改变。
Oncogene. 2017 Oct 19;36(42):5808-5818. doi: 10.1038/onc.2017.186. Epub 2017 Jun 12.
Zotero 插件