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本文引用的文献

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Quantitative solid-phase assay to measure deoxynucleoside triphosphate pools.用于测量脱氧核苷三磷酸池的定量固相分析。
Biol Methods Protoc. 2018 Oct 11;3(1):bpy011. doi: 10.1093/biomethods/bpy011. eCollection 2018.
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Genome wide decrease of DNA replication eye density at the midblastula transition of .合子基因组激活期. 中 DNA 复制眼密度的全基因组减少。
Cell Cycle. 2019 Jul;18(13):1458-1472. doi: 10.1080/15384101.2019.1618641. Epub 2019 May 26.
3
A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control.脱氧核苷酸代谢物与胚胎细胞周期控制之间的联系。
Curr Biol. 2019 Apr 1;29(7):1187-1192.e3. doi: 10.1016/j.cub.2019.02.021. Epub 2019 Mar 14.
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Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.发育细胞周期和合子转录的代谢调控。
Curr Biol. 2019 Apr 1;29(7):1193-1198.e5. doi: 10.1016/j.cub.2019.02.028. Epub 2019 Mar 14.
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High speed of fork progression induces DNA replication stress and genomic instability.叉突高速推进诱导 DNA 复制应激和基因组不稳定性。
Nature. 2018 Jul;559(7713):279-284. doi: 10.1038/s41586-018-0261-5. Epub 2018 Jun 27.
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Modified nucleoside triphosphates exist in mammals.修饰的核苷三磷酸存在于哺乳动物中。
Chem Sci. 2018 Apr 2;9(17):4160-4167. doi: 10.1039/c7sc05472f. eCollection 2018 May 7.
7
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.人类 SHMT 抑制剂揭示了缺陷性甘氨酸摄取是弥漫性大 B 细胞淋巴瘤可靶向的代谢脆弱性。
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9.
8
Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.组蛋白甲基转移酶 Set2 通过 MBF 依赖性转录促进 DNA 复制和诱导遗传毒性应激反应。
Cell Rep. 2017 Sep 12;20(11):2693-2705. doi: 10.1016/j.celrep.2017.08.058.
9
Dynamic Control of dNTP Synthesis in Early Embryos.早期胚胎中脱氧核糖核苷酸三磷酸（dNTP）合成的动态调控
Dev Cell. 2017 Aug 7;42(3):301-308.e3. doi: 10.1016/j.devcel.2017.06.013. Epub 2017 Jul 20.
10
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.缺乏 dNTP 会导致 APC/C 辅助因子 Cdh1 缺失时复制动态和 DNA 断裂的改变。
Oncogene. 2017 Oct 19;36(42):5808-5818. doi: 10.1038/onc.2017.186. Epub 2017 Jun 12.

dNTP 代谢物在胚胎细胞周期调控中的作用。

The role of dNTP metabolites in control of the embryonic cell cycle.

机构信息

Institut für Entwicklungsbiochemie, Universitätsmedizin, Georg-August-Universität , Göttingen , Germany.

Entwicklungsgenetik, Fachbereich Biologie, Philipps-Universität , Marburg , Germany.

出版信息

Cell Cycle. 2019 Nov;18(21):2817-2827. doi: 10.1080/15384101.2019.1665948. Epub 2019 Sep 22.

DOI:10.1080/15384101.2019.1665948
PMID:31544596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6791698/
Abstract

Deoxyribonucleotide metabolites (dNTPs) are the substrates for DNA synthesis. It has been proposed that their availability influences the progression of the cell cycle during development and pathological situations such as tumor growth. The mechanism has remained unclear for the link between cell cycle and dNTP levels beyond their role as substrates. Here, we review recent studies concerned with the dynamics of dNTP levels in early embryos and the role of DNA replication checkpoint as a sensor of dNTP levels.

摘要

脱氧核苷酸代谢物 (dNTPs) 是 DNA 合成的底物。据推测，它们的可用性会影响发育过程中和肿瘤生长等病理情况下细胞周期的进程。除了作为底物的作用外，细胞周期与 dNTP 水平之间的联系机制尚不清楚。本文综述了近期关于早期胚胎中 dNTP 水平动态变化以及 DNA 复制检验点作为 dNTP 水平传感器作用的研究。