癸酸氟奋乃静。其稳态药理学特征及其与迟发性运动障碍的关系。

Fluphenazine decanoate. Its steady-state pharmacologic profile and relationship to tardive dyskinesia.

作者信息

Glazer W M

机构信息

Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519.

出版信息

Schizophr Res. 1988 Nov-Dec;1(6):425-9. doi: 10.1016/0920-9964(88)90025-4.

DOI:10.1016/0920-9964(88)90025-4

PMID:3154530

Abstract

A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11 patients with and 17 patients without tardive dyskinesia. The results do not support the hypothesis that fluphenazine decanoate serum levels correlate with TD occurrence.

摘要

开发了一种灵敏的放射免疫测定法，以确定9名门诊患者中癸酸氟奋乃静的稳态、固定剂量药代动力学特征。为了观察通过该测定法测得的抗精神病药物血药水平是否与临床事件相关，我们对11例有迟发性运动障碍和17例无迟发性运动障碍患者的氟奋乃静血药水平进行了横断面研究。结果不支持癸酸氟奋乃静血清水平与迟发性运动障碍发生相关的假设。