MBOAT7 基因多态性与经肝活检证实的非酒精性脂肪性肝病患者慢性肾脏病的关系。
Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.
机构信息
Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
出版信息
Clin Gastroenterol Hepatol. 2020 Nov;18(12):2837-2839.e2. doi: 10.1016/j.cgh.2019.09.017. Epub 2019 Sep 20.
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD. Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409 and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292, have been reported to be associated with renal function in NAFLD subjects.
非酒精性脂肪性肝病（NAFLD）和慢性肾脏病（CKD）有共同的危险因素，最近的荟萃分析证实，NAFLD 是 CKD 发病的独立危险因素。与 NAFLD 相关的遗传变异，如 patatin-like phospholipase domain-containing-3（PNPLA3）rs738409 和跨膜 6 超家族成员 2（TM6SF2）rs5854292，据报道与 NAFLD 患者的肾功能有关。
Zotero 插件