Department of Woman Child and of General and Specialized Surgery, Università Degli Studi Della Campania "Luigi Vanvitelli", Napoli, Italy.
Expert Rev Gastroenterol Hepatol. 2021 Sep;15(9):975-984. doi: 10.1080/17474124.2021.1906649. Epub 2021 Apr 14.
: Over the past decades, a large amount of both adult and pediatric data has shown relationship between Nonalcoholic Fatty Liver Disease (NAFLD) and chronic kidney disease (CKD), resulting in an overall increased cardiometabolic burden. In view of the remarkable role of the genetic background in the NAFLD pathophysiology, a potential influence of the major NAFLD polymorphisms (e.g. the I148M variant of the () gene, the E167K allele of the (), the (), and the () genes) on renal function has been supposed. A shared metabolic and proinflammatory pathogenesis has been hypothesized, but the exact mechanism is still unknown.: We provide a comprehensive review of the potential genetic link between NAFLD and CKD in children. Convincing both adult and pediatric evidence supports this association, but there is some dispute especially in childhood.: Evidence supporting a potential genetic link between NAFLD and CKD represents an intriguing aspect with a major clinical implication because of its putative role in improving strategy programs to counteract the higher cardiometabolic risk of these patients.
在过去几十年中，大量的成人和儿科数据表明非酒精性脂肪性肝病（NAFLD）和慢性肾脏病（CKD）之间存在关系，导致整体代谢心血管负担增加。鉴于遗传背景在 NAFLD 病理生理学中的重要作用，主要的 NAFLD 多态性（例如基因的 I148M 变体、基因的 E167K 等位基因、基因和基因）对肾功能的潜在影响已被假设。已经假设存在共同的代谢和促炎发病机制，但确切的机制仍不清楚。
我们提供了儿童中 NAFLD 和 CKD 之间潜在遗传联系的综合综述。令人信服的成人和儿科证据都支持这种关联，但在儿童中存在一些争议。
支持 NAFLD 和 CKD 之间潜在遗传联系的证据代表了一个有趣的方面，具有重要的临床意义，因为它可能在改善策略计划以对抗这些患者更高的代谢心血管风险方面发挥作用。
