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机器人辅助腹腔镜前列腺切除术后肺部并发症的发生率及危险因素:对一家大型单中心2208例患者的回顾性观察分析

Incidence and Risk Factors of Pulmonary Complications after Robot-Assisted Laparoscopic Prostatectomy: A Retrospective Observational Analysis of 2208 Patients at a Large Single Center.

作者信息

Yu Jihion, Park Jun-Young, Kim Doo-Hwan, Kim Sungwon, Hwang Jai-Hyun, Seo Hyungseok, Kim Young-Kug

机构信息

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul 05278, Korea.

出版信息

J Clin Med. 2019 Sep 20;8(10):1509. doi: 10.3390/jcm8101509.

Abstract

Robot-assisted laparoscopic prostatectomy (RALP) is a minimally invasive technique for the treatment of prostate cancer. RALP requires the patient to be placed in the steep Trendelenburg position, along with pneumoperitoneum, which may increase the risk of postoperative pulmonary complications (PPCs). This large single-center retrospective study evaluated the incidence and risk factors of PPCs in 2208 patients who underwent RALP between 2014 and 2017. Patients were divided into those with (PPC group) and without (non-PPC group) PPCs. Postoperative outcomes were evaluated, and univariate and multivariate logistic regression analyses were performed to assess risk factors of PPCs. PPCs occurred in 682 patients (30.9%). Risk factors of PPCs included age (odds ratio [OR], 1.023; = 0.001), body mass index (OR, 1.061; = 0.001), hypoalbuminemia (OR, 1.653; = 0.008), and positive end-expiratory pressure (PEEP) application (OR, 0.283; < 0.001). The incidence of postoperative complications, rate of intensive care unit (ICU) admission, and duration of ICU stay were significantly greater in the PPC group than in the non-PPC group. In conclusion, the incidence of PPCs in patients who underwent RALP under pneumoperitoneum in the steep Trendelenburg position was 30.9%. Factors associated with PPCs included older age, higher body mass index, hypoalbuminemia, and lack of PEEP.

摘要

机器人辅助腹腔镜前列腺切除术(RALP)是一种用于治疗前列腺癌的微创技术。RALP要求患者处于头低脚高的大角度倾斜体位,并进行气腹操作,这可能会增加术后肺部并发症(PPCs)的风险。这项大型单中心回顾性研究评估了2014年至2017年间接受RALP的2208例患者中PPCs的发生率及危险因素。患者被分为发生PPCs的患者(PPC组)和未发生PPCs的患者(非PPC组)。评估术后结局,并进行单因素和多因素逻辑回归分析以评估PPCs的危险因素。682例患者(30.9%)发生了PPCs。PPCs的危险因素包括年龄(比值比[OR],1.023;P = 0.001)、体重指数(OR,1.061;P = 0.001)、低白蛋白血症(OR,1.653;P = 0.008)和呼气末正压(PEEP)的应用(OR,0.283;P < 0.001)。PPC组术后并发症的发生率、重症监护病房(ICU)入住率及ICU住院时间均显著高于非PPC组。总之,在头低脚高的大角度倾斜体位下接受气腹RALP手术的患者中,PPCs的发生率为30.9%。与PPCs相关的因素包括年龄较大、体重指数较高、低白蛋白血症和未应用PEEP。

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