Department of Clinical Laboratory, Jiangxi Province Key Laboratory of Laboratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Leuk Lymphoma. 2020 Feb;61(2):263-273. doi: 10.1080/10428194.2019.1666377. Epub 2019 Sep 24.
DNA methyltransferases (DNMTs) are highly conserved DNA-modifying enzymes that play important roles in epigenetic regulation and they are involved in cell proliferation, differentiation, and apoptosis. In mammalian cells, three active DNMTs have been identified: DNMT1 acts as a maintenance methyltransferase to replicate preexisting methylation patterns, whereas DNMT3A and DNMT3B primarily act as methyltransferases that are responsible for establishing DNA methylation patterns by adding a methyl group to cytosine bases. The expression of is widespread in a variety of hematological cells and it is altered in each type of leukemia, which is associated with its pathogenesis, progression, treatment, and prognosis. Here, we review current information on DNMT3B in leukemia, including its expression, single-nucleotide polymorphisms, mutations, regulation, function, and clinical value for anti-leukemic therapy and prognosis.
DNA 甲基转移酶（DNMTs）是高度保守的 DNA 修饰酶，在表观遗传调控中发挥重要作用，参与细胞增殖、分化和凋亡。在哺乳动物细胞中，已经鉴定出三种活性的 DNMT：DNMT1 作为维持甲基转移酶复制预先存在的甲基化模式，而 DNMT3A 和 DNMT3B 主要作为甲基转移酶，通过向胞嘧啶碱基添加甲基基团来负责建立 DNA 甲基化模式。在各种血液细胞中广泛表达，并在每种类型的白血病中发生改变，这与其发病机制、进展、治疗和预后相关。在这里，我们综述了 DNMT3B 在白血病中的最新信息，包括其表达、单核苷酸多态性、突变、调控、功能以及在抗白血病治疗和预后中的临床价值。
