Prusky G T, Cynader M S
Department of Psychology, Dalhousie University, Halifax, Nova Scotia.
Vis Neurosci. 1988;1(2):245-8. doi: 10.1017/s0952523800001504.
The autoradiographic distribution of [3H]nicotine binding sites was examined in the superior colliculus in normal rats and cats, and in animals in which one or both eyes were removed. [3H]Nicotine binding sites in normal animals were densely concentrated in the superficial layers of the colliculus corresponding to the zone of termination of optic nerve fibers. Following bilateral enucleation, [3H]nicotine binding in the superficial collicular layers was drastically reduced. Unilateral enucleation markedly reduced [3H]nicotine binding sites in the colliculus contralateral to the removed eye, with little effect on the ipsilateral colliculus. These results provide further evidence that nicotinic acetylcholine receptors have a presynaptic location on optic tract terminals and may therefore modulate retinotectal transmission in both the rat and cat visual system.
在正常大鼠和猫以及一只或两只眼睛被摘除的动物的上丘中，研究了[3H]尼古丁结合位点的放射自显影分布。正常动物中的[3H]尼古丁结合位点密集地集中在上丘的表层，对应于视神经纤维的终止区域。双侧眼球摘除后，上丘表层的[3H]尼古丁结合显著减少。单侧眼球摘除显著减少了与摘除眼对侧的上丘中的[3H]尼古丁结合位点，对同侧上丘影响很小。这些结果进一步证明，烟碱型乙酰胆碱受体在视束终末具有突触前定位，因此可能在大鼠和猫的视觉系统中调节视网膜顶盖传导。
