Technological University Dublin, Ireland.
Technological University Dublin, Ireland.
Cont Lens Anterior Eye. 2020 Apr;43(2):159-168. doi: 10.1016/j.clae.2019.09.003. Epub 2019 Sep 20.
To evaluate the effect blepharitis lid cleansers have on the tear film and ocular surface, and to examine the prevalence of Demodex folliculorum in a young population.
Forty-eight university students completed a randomised, controlled, investigator-masked, eight-week clinical trial. Three eyelid hygiene products were investigated: blepharitis eyelid cleanser (OCuSOFT® Lid Scrub® PLUS foam), diluted baby shampoo (10% Johnson's® No More Tears ®) and a tea-tree based face wash (dr.organic®). Cooled boiled water was used as a control. Subjects attended for four visits: baseline, two weeks, four weeks and eight weeks. At each visit, subjective symptoms, non-invasive tear break up time, ocular surface staining and Demodex folliculorum investigation were assessed to evaluate any positive or negative effect on the tear film and ocular surface. Osmolarity was also measured at baseline and week eight only.
The overall prevalence of Demodex folliculorum found at baseline was 15%. Subjective symptoms improved in all groups, including control. There was no significant difference in mean osmolarity between the groups or within each group after eight weeks. There was a significant increase in osmolarity inter-eye variability in the baby shampoo group (5.5 ± 5.4 vs 15.2 ± 9.5; p = 0.03). There was no significant change in non-invasive tear break up time or ocular surface staining demonstrated after eight weeks of eyelid hygiene.
A low prevalence of Demodex folliculorum can be found in a young population. All blepharitis lid cleansers used demonstrated subjective improvement in symptoms, with no negative effects on tear break-up time or ocular surface staining. The blepharitis eyelid cleanser and tea-tree based face wash revealed no adverse effect on mean osmolarity or inter-eye variability. Similarly, baby shampoo did not cause a significant increase in mean osmolarity, however, a significant increase in inter-eye variability was found; suggesting a possible increase in ocular surface inflammation.
评估睑缘炎眼睑清洁剂对泪膜和眼表面的影响，并研究年轻人群中毛囊蠕形螨的流行情况。
48 名大学生完成了一项随机、对照、研究者盲法、为期 8 周的临床试验。研究了 3 种眼睑卫生产品：睑缘炎眼睑清洁剂（OCuSOFT® Lid Scrub® PLUS 泡沫）、稀释婴儿洗发水（10%强生®无泪®）和茶树基洗面奶（dr.organic®）。冷却后的开水作为对照。受试者就诊 4 次：基线、2 周、4 周和 8 周。每次就诊时，评估主观症状、非侵入性泪膜破裂时间、眼表面染色和毛囊蠕形螨检查，以评估对泪膜和眼表面的任何积极或消极影响。仅在基线和第 8 周测量渗透压。
基线时发现毛囊蠕形螨的总体患病率为 15%。所有组，包括对照组，主观症状均有所改善。8 周后，各组之间或组内平均渗透压无显著差异。婴儿洗发水组双眼间渗透压变异性显著增加（5.5±5.4 比 15.2±9.5；p=0.03）。8 周眼睑卫生后，非侵入性泪膜破裂时间或眼表面染色无明显变化。
在年轻人群中，可以发现低患病率的毛囊蠕形螨。所有使用的睑缘炎眼睑清洁剂均显示症状主观改善，对泪膜破裂时间或眼表面染色无不良影响。睑缘炎眼睑清洁剂和茶树基洗面奶对平均渗透压或双眼间变异性无不良影响。同样，婴儿洗发水不会导致平均渗透压显著增加，但发现双眼间变异性显著增加；提示眼表面炎症可能增加。
