The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
NHC Key Laboratory on Assisted Circulation, Sun Yat-sen University, Guangzhou, China.
Diabetes Care. 2019 Dec;42(12):2334-2337. doi: 10.2337/dc19-0834. Epub 2019 Sep 23.
To determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume.
Multivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SD), the coefficient of variation of the mean FG (CV), and the average real variability (ARV) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25.
After multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SD -0.015 [95% CI -0.026, -0.004]; CV -0.009 [95% CI -0.018, -0.001]; ARV -0.011 [95% CI -0.019, -0.002]) and lower hippocampal volume (SD -0.012 [95% CI -0.023, -0.001]).
Higher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.
确定成年早期的空腹血糖（VVFG）变异性是否与中年海马体的完整性和体积有关。
多变量调整线性回归模型用于评估 543 名 CARDIA 研究参与者中 VVFG 变异性与脑 MRI 变量之间的关联。VVFG 变异性通过 FG 的标准差（SD）、平均 FG 的变异系数（CV）和 25 年随访期间的平均真实变异性（ARV）来定义。海马体完整性各向异性分数（FA）和组织体积标准化为颅内体积，通过 3T MRI 在第 25 年进行测量。
经过多变量调整，更高的 FG 变异性（1-SD 增加）与较低的海马体 FA（SD -0.015[95% CI -0.026，-0.004]；CV -0.009[95% CI -0.018，-0.001]；ARV -0.011[95% CI -0.019，-0.002]）和较低的海马体体积（SD -0.012[95% CI -0.023，-0.001]）相关。
成年早期的 VVFG 变异性较高与中年海马体完整性和体积较低有关，表明其在预测海马体结构损伤风险方面具有价值。
