Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,
Med Princ Pract. 2020;29(3):203-210. doi: 10.1159/000503621. Epub 2019 Sep 25.
The purpose of the present study was to determine the local recurrence rate, risk of dedifferentiation, and distant metastasis after surgical excision of intramuscular lipomas (IML) and atypical lipomatous tumors (ALT).
We retrospectively assessed all IML and ALT surgically removed from the extremities or trunk wall in our clinic between 1997 and 2006. Data from 141 patients with IML and 35 patients with ALT were extracted from the National Pathology Registry and patient files.
IML and ALT recurred in 10 and 6 tumors, respectively. No metastases were observed in either group. The 5- and 10-year local recurrence-free survival rates were 97.1% (94.3-99.9) and 94.8% (CI: 91.1-98.6) for IML and 84.6% (CI: 72.1-97.1) and 81.1% (CI: 67.6-94.8) for ALT, respectively. ALT were found to dedifferentiate in 2/35 cases.
Both IML and ALT showed a low recurrence rate when removed surgically from the extremities or trunk wall with intended marginal resection. No distant metastases were observed in any of the groups. It, therefore, seems safe to treat these tumors with marginal resection.
本研究旨在确定外科切除肢体或躯干壁内肌脂肪瘤（IML）和非典型性脂肪肉瘤（ALT）后的局部复发率、去分化风险和远处转移率。
我们回顾性评估了 1997 年至 2006 年间在我院外科切除的所有肢体或躯干壁内肌脂肪瘤和非典型性脂肪肉瘤。从国家病理登记处和患者档案中提取了 141 例 IML 和 35 例 ALT 患者的数据。
IML 和 ALT 分别有 10 例和 6 例肿瘤复发。两组均未观察到转移。IML 的 5 年和 10 年局部无复发生存率分别为 97.1%（94.3-99.9）和 94.8%（CI：91.1-98.6），ALT 分别为 84.6%（CI：72.1-97.1）和 81.1%（CI：67.6-94.8）。有 2/35 例 ALT 发生去分化。
当以边缘性切除术切除肢体或躯干壁的 IML 和 ALT 时，复发率均较低。两组均未观察到远处转移。因此，对这些肿瘤进行边缘性切除似乎是安全的。
