Xiaorong Dong, Li Ma, Xuefeng Liu, Jian He
Emergency and Critical Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou, Gansu, PR China.
Otolaryngology Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, PR China.
Pak J Pharm Sci. 2019 May;32(3 Special):1437-1440.
The aim of the study was to investigate the effect of dexamethasone combined with ambroxol hydrochloride on T cell subsets and hearing in patients with secretory otitis media. Eighty-six cases of patients with secretory otitis media admitted to "Gansu Provincal Hospital, Lanzhou, China" from September 2016 to September 2018 were regarded as subjects of the study. The patients were divided in two groups according to the digital table method. Among them, the control group was treated with ambroxol hydrochloride, while the study group was treated with dexamethasone combined with ambroxol hydrochloride. The clinical efficacy, T cytokines before and after treatment, auditory threshold and middle ear resonance frequency were observed and compared between the two groups of the patients. SPSS 18.0 software was used to statistically analyze the data. The therapeutic efficacy of the study group was better than that of the control group and the levels of CD4, CD4/CD8+ after treatment of the study group were higher than that of the control group (P<0.05), while the content of CD8+ in the study group was lower than that in the control group (P<0.05). In addition, the auditory threshold of the study group was lower than that of the control group (P<0.05), whereas the middle ear resonance frequency was higher than that of the control group (P<0.05). The application of dexamethasone combined with ambroxol hydrochloride improved the clinical symptoms and restored hearing in the clinical treatment of patients with secretory otitis media and the therapeutic efficacy was ideal.
本研究旨在探讨地塞米松联合盐酸氨溴索对分泌性中耳炎患者T细胞亚群及听力的影响。选取2016年9月至2018年9月在“中国兰州甘肃省人民医院”收治的86例分泌性中耳炎患者作为研究对象。采用数字表法将患者分为两组。其中，对照组采用盐酸氨溴索治疗，研究组采用地塞米松联合盐酸氨溴索治疗。观察并比较两组患者的临床疗效、治疗前后的T细胞因子、听阈及中耳共振频率。采用SPSS 18.0软件对数据进行统计学分析。研究组的治疗效果优于对照组，研究组治疗后CD4、CD4/CD8+水平高于对照组（P<0.05），而研究组CD8+含量低于对照组（P<0.05）。此外，研究组的听阈低于对照组（P<0.05），而中耳共振频率高于对照组（P<0.05）。地塞米松联合盐酸氨溴索在分泌性中耳炎患者的临床治疗中改善了临床症状并恢复了听力，治疗效果理想。
