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铜绿假单胞菌与囊性纤维化:独特的细菌适应性与发病机制

Pseudomonas aeruginosa and cystic fibrosis: unusual bacterial adaptation and pathogenesis.

作者信息

Govan J R, Harris G S

机构信息

Department of Bacteriology, University of Edinburgh Medical School, UK.

出版信息

Microbiol Sci. 1986 Oct;3(10):302-8.

PMID:3155268
Abstract

Pseudomonas aeruginosa is an adaptable, saprophytic bacterium with the potential to cause a variety of opportunistic infections in compromised hosts. In patients with cystic fibrosis, chronic pulmonary colonization with mucoid alginate-producing mutants of P. aeruginosa is a major cause of morbidity and mortality and is an interesting example of microbial adaptation and host-bacterium interaction.

摘要

铜绿假单胞菌是一种适应性强的腐生菌,有潜力在免疫功能低下的宿主中引发多种机会性感染。在囊性纤维化患者中,铜绿假单胞菌产黏液藻酸盐突变体的慢性肺部定植是发病和死亡的主要原因,也是微生物适应性和宿主-细菌相互作用的一个有趣例子。

相似文献

1
Pseudomonas aeruginosa and cystic fibrosis: unusual bacterial adaptation and pathogenesis.铜绿假单胞菌与囊性纤维化:独特的细菌适应性与发病机制
Microbiol Sci. 1986 Oct;3(10):302-8.
2
Rationale for development of immunotherapies that target mucoid Pseudomonas aeruginosa infection in cystic fibrosis patients.针对囊性纤维化患者黏液型铜绿假单胞菌感染的免疫疗法的研发原理。
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Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients.铜绿假单胞菌在囊性纤维化患者中的慢性定植。
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Mucoid Pseudomonas aeruginosa growing in a biofilm in vitro are killed by opsonic antibodies to the mucoid exopolysaccharide capsule but not by antibodies produced during chronic lung infection in cystic fibrosis patients.在体外生物膜中生长的黏液型铜绿假单胞菌可被针对黏液型胞外多糖荚膜的调理素抗体杀死,但囊性纤维化患者慢性肺部感染期间产生的抗体则不能将其杀死。
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Cystic fibrosis: infection.囊性纤维化:感染
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Pseudomonas aeruginosa infection in cystic fibrosis. Relationship between mucoid strains of Pseudomonas aeruginosa and the humoral immune response.囊性纤维化中的铜绿假单胞菌感染。铜绿假单胞菌黏液型菌株与体液免疫反应之间的关系。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Aug;82(4):551-8.

引用本文的文献

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The GDP-Mannose Dehydrogenase of : An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains.[具体物种名称]的GDP-甘露糖脱氢酶:对抗黏液菌株抗生素耐药性的新旧靶点
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Bacterial Subversion of Autophagy in Cystic Fibrosis.囊性纤维化中细菌对自噬的破坏
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3
Pseudomonas aeruginosa Regulated Intramembrane Proteolysis: Protease MucP Can Overcome Mutations in the AlgO Periplasmic Protease To Restore Alginate Production in Nonmucoid Revertants.
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J Bacteriol. 2018 Jul 25;200(16). doi: 10.1128/JB.00215-18. Print 2018 Aug 15.
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Controlling Persister and Biofilm Cells of Gram-Negative Bacteria with a New 1,3,5-Triazine Derivative.用一种新型 1,3,5-三嗪衍生物控制革兰氏阴性菌的持久细胞和生物膜细胞。
Pharmaceuticals (Basel). 2015 Oct 10;8(4):696-710. doi: 10.3390/ph8040696.
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Antimicrobial susceptibility differences among mucoid and non-mucoid Pseudomonas aeruginosa isolates.黏液型和非黏液型铜绿假单胞菌分离株之间的抗菌药敏差异。
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