Department of Surgery, Damsoyu Hospital, Gangnam-gu, Seoul, Republic of Korea.
Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Guro-gu, Seoul, Republic of Korea.
Am J Mens Health. 2019 Sep-Oct;13(5):1557988319871423. doi: 10.1177/1557988319871423.
Finasteride is commonly used for treatment of alopecia. Because finasteride is a cause of gynecomastia, there is concern regarding the continuation of finasteride therapy after mastectomy. No studies have been performed to determine whether finasteride should be continued after mastectomy when gynecomastia occurs in patients taking finasteride for the treatment of alopecia. The researchers studied the effects of finasteride on gynecomastia recurrence after mastectomy in men with gynecomastia taking finasteride for alopecia. The researchers retrospectively evaluated 1,673 patients with gynecomastia who underwent subcutaneous mastectomy with liposuction at Damsoyu Hospital from January 2014 to December 2016. In total, 52 of the patients were taking finasteride for alopecia before surgery and continued to use it in the same manner after mastectomy. Ultrasonography was performed 1 year after mastectomy. The patients' median age was 26.5 (24.75-30) years. All 52 patients had bilateral gynecomastia. The median duration of finasteride therapy before and after surgery was 12 (5-25.75) and 33 (27.5-40.5) months, respectively. There were no statistically significant differences between the groups with and without the use of finasteride in relation to postoperative complications and recurrence rates. Taking finasteride seems to have little effect on recurrence in patients with alopecia who have undergone surgical treatment of gynecomastia. Surgeons may recommend continuous finasteride therapy in patients with alopecia who wish to take finasteride after mastectomy.
非那雄胺常用于治疗脱发。由于非那雄胺是导致男性乳房发育症的原因之一，因此人们担心在乳房切除术后继续使用非那雄胺治疗。目前尚无研究确定在接受非那雄胺治疗脱发的男性发生男性乳房发育症后是否应继续使用非那雄胺。研究人员研究了非那雄胺对接受乳房切除术治疗脱发的男性发生男性乳房发育症后乳房切除术复发的影响。研究人员回顾性评估了 2014 年 1 月至 2016 年 12 月在 Damsoyu 医院接受乳房皮下切除术和吸脂术的 1673 例男性乳房发育症患者。总共 52 例患者在手术前因脱发服用非那雄胺，并在乳房切除术后继续以相同方式使用。乳房切除术后 1 年进行超声检查。患者的中位年龄为 26.5（24.75-30）岁。所有 52 例患者均有双侧男性乳房发育症。手术前后非那雄胺治疗的中位时间分别为 12（5-25.75）和 33（27.5-40.5）个月。是否使用非那雄胺与术后并发症和复发率之间无统计学差异。对于接受手术治疗男性乳房发育症的脱发患者，服用非那雄胺似乎对复发影响不大。对于希望在乳房切除术后继续服用非那雄胺的脱发患者，外科医生可能会建议继续服用非那雄胺治疗。
