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Quantitative HBsAg: Not helpful to evaluate fibrosis in HBeAg-negative chronic hepatitis B patients.定量乙肝表面抗原：对评估HBeAg阴性慢性乙型肝炎患者的纤维化情况无帮助。
Saudi J Gastroenterol. 2019 Sep-Oct;25(5):269-271. doi: 10.4103/sjg.SJG_445_19.
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Quantitative HBcrAg and HBcAb versus HBsAg and HBV DNA in predicting liver fibrosis levels of chronic hepatitis B patients.定量 HBcrAg 和 HBcAb 与 HBsAg 和 HBV DNA 联合检测预测慢性乙型肝炎患者肝纤维化程度。
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The importance of the serum quantitative levels of hepatitis B surface antigen and hepatitis B e antigen in children with chronic hepatitis B.慢性乙型肝炎患儿血清乙型肝炎表面抗原和乙型肝炎e抗原定量水平的重要性。
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Enhanced HBsAg synthesis correlates with increased severity of fibrosis in chronic hepatitis B patients.慢性乙型肝炎患者中，增强的乙肝表面抗原（HBsAg）合成与肝纤维化严重程度增加相关。
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Correlations between serum hepatitis B surface antigen and hepatitis B core antibody titers and liver fibrosis in treatment-naïve CHB patients.在未经治疗的 CHB 患者中，血清乙型肝炎表面抗原和乙型肝炎核心抗体滴度与肝纤维化的相关性。
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Hepatitis B Surface Antigen Levels Can Be Used to Rule Out Cirrhosis in Hepatitis B e Antigen-Positive Chronic Hepatitis B: Results From the SONIC-B Study.乙肝表面抗原水平可用于排除乙肝e抗原阳性慢性乙型肝炎患者的肝硬化：SONIC-B研究结果
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Association of Coexistent Hepatitis B Surface Antigen and Antibody With Severe Liver Fibrosis and Cirrhosis in Treatment-Naive Patients With Chronic Hepatitis B.在未经治疗的慢性乙型肝炎患者中，乙型肝炎表面抗原和抗体共存与严重肝纤维化和肝硬化的关系。
JAMA Netw Open. 2022 Jun 1;5(6):e2216485. doi: 10.1001/jamanetworkopen.2022.16485.
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Quantitative HBsAg levels do not identify hepatic fibrosis in HBeAg-negative chronic hepatitis B patients.定量 HBsAg 水平不能识别 HBeAg 阴性慢性乙型肝炎患者的肝纤维化。
Saudi J Gastroenterol. 2019 Sep-Oct;25(5):286-292. doi: 10.4103/sjg.SJG_80_19.
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Hepatitis B surface antigen serum level is associated with fibrosis severity in treatment-naïve, e antigen-positive patients.乙肝表面抗原血清水平与未经治疗的 e 抗原阳性患者的纤维化严重程度相关。
J Hepatol. 2013 Jun;58(6):1089-95. doi: 10.1016/j.jhep.2013.01.028. Epub 2013 Jan 28.

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Clinical and Histopathological Correlation of Quantitative HBsAg Levels in Chronic Hepatitis B.慢性乙型肝炎中定量HBsAg水平的临床与组织病理学相关性
Int J Hepatol. 2025 Jul 28;2025:9096871. doi: 10.1155/ijh/9096871. eCollection 2025.
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Non-Invasive Prediction Scores for Hepatitis B Virus- and Hepatitis D Virus-Infected Patients-A Cohort from the North-Eastern Part of Romania.罗马尼亚东北部乙型肝炎病毒和丁型肝炎病毒感染患者的无创预测评分——一项队列研究
Microorganisms. 2023 Nov 30;11(12):2895. doi: 10.3390/microorganisms11122895.
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Correlation Between Quantitative Hepatitis B Surface Antigen and Hepatitis B Virus Deoxyribonucleic Acid Levels in Hepatitis B e Antigen-Positive and Hepatitis B e AntigenNegative Chronic Hepatitis B Patients.乙型肝炎 e 抗原阳性和乙型肝炎 e 抗原阴性慢性乙型肝炎患者乙型肝炎表面抗原定量与乙型肝炎病毒脱氧核糖核酸水平的相关性。
Turk J Gastroenterol. 2023 Apr;34(4):378-382. doi: 10.5152/tjg.2020.19612.

本文引用的文献

1
Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure.实现乙型肝炎病毒治愈的目标和未来直接作用抗病毒方法。
Lancet Gastroenterol Hepatol. 2019 Nov;4(11):883-892. doi: 10.1016/S2468-1253(19)30190-6.
2
Quantitative HBsAg levels do not identify hepatic fibrosis in HBeAg-negative chronic hepatitis B patients.定量 HBsAg 水平不能识别 HBeAg 阴性慢性乙型肝炎患者的肝纤维化。
Saudi J Gastroenterol. 2019 Sep-Oct;25(5):286-292. doi: 10.4103/sjg.SJG_80_19.
3
Greater prevalence of comorbidities with increasing age: Cross-sectional analysis of chronic hepatitis B patients in Saudi Arabia.随着年龄的增长，合并症的患病率更高：沙特阿拉伯慢性乙型肝炎患者的横断面分析。
Saudi J Gastroenterol. 2019 May-Jun;25(3):194-200. doi: 10.4103/sjg.SJG_447_18.
4
Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases.慢性肝脏疾病中的线粒体功能障碍与信号转导
Gastroenterology. 2018 Sep;155(3):629-647. doi: 10.1053/j.gastro.2018.06.083. Epub 2018 Aug 2.
5
Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.慢性乙型肝炎的预防、诊断和治疗最新进展：美国肝病研究学会2018年乙型肝炎指南
Hepatology. 2018 Apr;67(4):1560-1599. doi: 10.1002/hep.29800.
6
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.基于 RNAi 的慢性感染患者和黑猩猩治疗揭示，整合的乙型肝炎病毒 DNA 是 HBsAg 的来源。
Sci Transl Med. 2017 Sep 27;9(409). doi: 10.1126/scitranslmed.aan0241.
7
Can quantitative hepatitis B surface antigen levels predict the severity of liver disease in genotype E Patients?E基因型患者的乙肝表面抗原定量水平能否预测肝病严重程度？
J Viral Hepat. 2018 Jan;25(1):80-87. doi: 10.1111/jvh.12756. Epub 2017 Aug 23.
8
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.EASL 2017 临床实践指南：乙型肝炎病毒感染管理。
J Hepatol. 2017 Aug;67(2):370-398. doi: 10.1016/j.jhep.2017.03.021. Epub 2017 Apr 18.
9
MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C.基于 microRNA 的慢性乙型和丙型肝炎患者肝纤维化和肝硬化的诊断工具。
Sci Rep. 2016 Oct 12;6:34935. doi: 10.1038/srep34935.
10
Baseline HBsAg and HBcrAg titres allow peginterferon-based 'precision medicine' in HBeAg-negative chronic hepatitis B patients.基线乙肝表面抗原（HBsAg）和乙肝核心相关抗原（HBcrAg）滴度有助于对e抗原阴性慢性乙型肝炎患者进行基于聚乙二醇干扰素的“精准医学”治疗。
J Viral Hepat. 2016 Nov;23(11):905-911. doi: 10.1111/jvh.12565. Epub 2016 Jul 4.

Quantitative HBsAg: Not helpful to evaluate fibrosis in HBeAg-negative chronic hepatitis B patients.

作者信息

Loureiro Dimitri, Mansouri Abdellah, Asselah Tarik

机构信息

Department of Hepatology, Universite Paris Diderot, Sorbonne Paris Cite, CRI, UMR 1149, Inserm, F-75018 Paris; Department of Hepatology, AP-HP Hopital Beaujon, Clichy, France.

出版信息

Saudi J Gastroenterol. 2019 Sep-Oct;25(5):269-271. doi: 10.4103/sjg.SJG_445_19.

DOI:10.4103/sjg.SJG_445_19
PMID:31552841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6784434/
Abstract
摘要