Kery Rachel, Chen Allen P F, Kirschen Gregory W
Medical Scientist Training Program (MSTP), Stony Brook Medicine; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA.
Medical Scientist Training Program (MSTP), Stony Brook Medicine, Stony Brook, NY, USA.
Neural Regen Res. 2020 Feb;15(2):199-211. doi: 10.4103/1673-5374.265541.
Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological pathways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte's role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manipulation of astrocytes that may prove critical to modulating their response to neurological injury, potentially combatting neurodegenerative damage.
星形胶质细胞是在整个中枢神经系统中与神经元和其他支持细胞广泛相互作用的神经胶质细胞，最近因其在一系列神经退行性疾病中的潜在作用或潜在的再生作用而备受关注。越来越明显的是，星形胶质细胞与小胶质细胞协同作用，在神经退行性损伤的情况下激活内在免疫途径，尽管这种激活的直接和间接后果在很大程度上仍然未知。我们回顾了关于星形胶质细胞在几种神经退行性疾病中作用的当前文献，并强调了星形胶质细胞基因操作方面的最新进展，这些进展可能对调节其对神经损伤的反应至关重要，有可能对抗神经退行性损伤。
