胆石病患者的氨基酸谱和肠促胰岛素激素特征：一项初步研究。
Characteristics of amino acid profiles and incretin hormones in patients with gallstone disease: a pilot study.
机构信息
Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.
Department of General and Oncological Surgery, St. John Grande Hospital, Kraków, Poland
出版信息
Pol Arch Intern Med. 2019 Dec 23;129(12):883-888. doi: 10.20452/pamw.14990. Epub 2019 Sep 25.
INTRODUCTION
Gallstone disease is associated with insulin resistance, type 2 diabetes mellitus, and increased risk of incident ischemic heart disease. It is known that the profile of branched‑chain amino acids (BCAAs) is altered in cardiac diseases as well as metabolic diseases, such as diabetes and obesity. The role of BCAAs in gallstone disease is still not known.
OBJECTIVES
The aim of this study was to evaluate the concentration of essential amino acids and incretin hormones in patients with cholecystolithiasis.
PATIENTS AND METHODS
The study included 31 patients with cholecystolithiasis and 25 gallstone‑free controls. The levels of free exogenous and endogenous amino acids, bile acids, glucagon‑like peptide 1, glucose‑dependent insulinotropic polypeptide, ghrelin, C-peptide, and insulin were measured in the fasting state and 1 hour after consumption of a 300‑kcal mixed meal.
RESULTS
The mean fasting and postprandial levels of valine, isoleucine, leucine, and lysine were higher in the study group than in controls (all P.
简介
胆石病与胰岛素抵抗、2 型糖尿病和缺血性心脏病事件风险增加有关。已知支链氨基酸（BCAAs）的谱在心脏病以及代谢疾病（如糖尿病和肥胖症）中发生改变。BCAAs 在胆石病中的作用尚不清楚。
目的
本研究旨在评估胆囊结石病患者的必需氨基酸和肠降血糖素激素的浓度。
患者和方法
该研究包括 31 例胆囊结石病患者和 25 例无胆囊结石对照组。在空腹和进食 300 千卡混合餐后 1 小时，测量游离外源性和内源性氨基酸、胆汁酸、胰高血糖素样肽 1、葡萄糖依赖性胰岛素释放肽、胃饥饿素、C 肽和胰岛素的水平。
结果
研究组空腹和餐后缬氨酸、异亮氨酸、亮氨酸和赖氨酸的平均水平均高于对照组（均 P<0.05）。
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