肾小球肾炎：对常规进行的免疫学检测的批判性评估（作者译）

[Glomerulonephritis: critical evaluation of immunological tests performed routinely (author's transl)].

作者信息

Rebaiz K, Roujeau J C, Gluckman J C, Beaufils H, Jacob N, Legrain M

出版信息

Nouv Presse Med. 1979 Sep 17;8(35):2801-5.

Abstract

The clinical value of the immunological tests performed routinely has been evaluated in 91 patients with various histological types of glomerulonephritis. An antigen possibly involved in the pathogeny of renal disease was found in 24% cases. However, in most instances no direct link between the presence of this given antigen and the disease could be observed. Therefore systematic investigations for antigens should be restricted to dosages of antistreptolysin and antinuclear antibodies and to determination of Hbs antigen. Immune complexes, which were observed in many cases, were of no discriminant value for the clinician. Dosages of the complement fractions and the determination of cryoglobulins can be helpful for diagnostic, follow-up and treatment. Our results justify a restricted selection of the routine immunological tests used in patients with glomerulonephritis. More specific investigations remain useful when they are clinically oriented.

摘要

对91例不同组织学类型的肾小球肾炎患者进行了常规免疫检测的临床价值评估。在24%的病例中发现了一种可能与肾脏疾病发病机制有关的抗原。然而，在大多数情况下，未观察到这种特定抗原的存在与疾病之间有直接联系。因此，抗原的系统检测应限于抗链球菌溶血素和抗核抗体的测定以及乙肝表面抗原的检测。在许多病例中观察到的免疫复合物对临床医生没有鉴别价值。补体成分的测定和冷球蛋白的检测有助于诊断、随访和治疗。我们的结果证明对肾小球肾炎患者使用的常规免疫检测进行有限选择是合理的。当以临床为导向时，更具特异性的检测仍然有用。