Heo Nae-Yun
Division of Gastroenterology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Korean J Gastroenterol. 2019 Sep 25;74(3):130-136. doi: 10.4166/kjg.2019.74.3.130.
The HEV is a known cause of water-borne outbreaks of acute non-A non-B hepatitis in developing countries, which affects young people and may result in high mortality in pregnant women. In recent decades, however, HEV genotypes 3 and 4 have been known as a cause of sporadic zoonotic infections in older males from swine HEV worldwide. Most acute HEV infections are self-limited. On the other hand, in immunosuppressed patients, including solid organ transplant recipients, chronic HEV infections may exist and progress to liver cirrhosis or decompensation. Therefore, physicians need to recognize HEV as a major pathogen for acute and chronic hepatitis of unknown causes and investigate this disease.
戊型肝炎病毒是发展中国家水源性急性非甲非乙型肝炎暴发的已知病因，该病影响年轻人，且可能导致孕妇的高死亡率。然而，近几十年来，戊型肝炎病毒3型和4型被认为是全球范围内猪戊型肝炎病毒感染老年男性散发性人畜共患病的病因。大多数急性戊型肝炎病毒感染是自限性的。另一方面，在免疫抑制患者中，包括实体器官移植受者，可能存在慢性戊型肝炎病毒感染，并进展为肝硬化或失代偿。因此，医生需要认识到戊型肝炎病毒是不明原因急性和慢性肝炎的主要病原体，并对这种疾病进行调查。
