Small Animal Clinic AniCura Kalmarsund, Gasverksgatan 7, 392 45 Kalmar, Sweden; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, Herts AL9 7TA, UK.
Vet J. 2019 Oct;252:105354. doi: 10.1016/j.tvjl.2019.105354. Epub 2019 Aug 13.
There are sparse published scientific data on associations between neutering and the severity and survival of dogs with idiopathic epilepsy. This study aimed to explore the timing of neutering with respect to onset of seizures in dogs with idiopathic epilepsy. Associations between neutering and both age of onset of seizures and the occurrence of cluster seizures or status epilepticus were examined. Survival analysis investigated the effects of sex-neuter categories. The median survival time of Border collies was compared with data previously reported in literature. The study included veterinary primary-care clinical data on 117 Labrador retrievers and 57 Border collies diagnosed with idiopathic epilepsy from the VetCompass project in the UK. The majority (74.2%; P≤0.001) of neutered cases were neutered before the onset of seizures. Age (years) at onset of seizures did not differ between dogs intact at time of onset and dogs neutered before onset of seizures (males 3.6 vs. 3.7; P=0.468 and females 3.4 vs. 4.1; P=0.154). Neuter status was not associated with the occurrence of cluster seizures (males P=0.947 and females P=0.844). Dogs intact at onset of seizures had longer median survival times than dogs neutered before onset of seizures (males, 1436 days vs. 1234 days; P=0.019; females, 1778.5 days vs. 1261 days; P=0.027). Median survival time of 1393 days for Border collies was longer than previously reported (P≤0.001). These results do not support recommendations to neuter dogs with idiopathic epilepsy within an evidence-based treatment plan.
关于去势与特发性癫痫犬癫痫发作的严重程度和生存之间的关联，已发表的科学数据很少。本研究旨在探讨特发性癫痫犬去势与癫痫发作开始时间之间的关系。检查了去势与癫痫发作年龄、簇发性癫痫发作或癫痫持续状态发生之间的关系。生存分析研究了性别去势类别对犬的影响。还比较了边境牧羊犬的中位生存时间与文献中先前报道的数据。本研究纳入了英国 VetCompass 项目中兽医初级保健临床数据，共包括 117 只拉布拉多猎犬和 57 只边境牧羊犬，这些犬被诊断为特发性癫痫。大多数（74.2%；P≤0.001）去势病例是在癫痫发作前进行的去势。在癫痫发作时未去势的犬与在癫痫发作前已去势的犬相比，癫痫发作的年龄（岁）无差异（雄性 3.6 岁与 3.7 岁；P=0.468，雌性 3.4 岁与 4.1 岁；P=0.154）。去势状态与簇发性癫痫发作无关（雄性 P=0.947，雌性 P=0.844）。在癫痫发作时未去势的犬的中位生存时间长于在癫痫发作前已去势的犬（雄性，1436 天比 1234 天；P=0.019；雌性，1778.5 天比 1261 天；P=0.027）。1393 天的边境牧羊犬中位生存时间长于先前报道的时间（P≤0.001）。这些结果不支持在基于证据的治疗计划中对特发性癫痫犬进行去势的建议。
