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观点:从鼠到人——成体神经发生有多普遍?

Perspective: Of Mice and Men - How Widespread Is Adult Neurogenesis?

作者信息

Petrik David, Encinas Juan M

机构信息

School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Institute of Stem Cell Research, Helmholtz Zentrum München, Munich, Germany.

出版信息

Front Neurosci. 2019 Aug 29;13:923. doi: 10.3389/fnins.2019.00923. eCollection 2019.

Abstract

These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in the adult, and even diseased human brain flourishes as articles against and in favor accumulate. Adult neurogenesis in the human brain is a phenomenon that does not share the qualities of quantum mechanics. The scientific community should agree that human AHN exists or does not, but not both at the same time. In this commentary, we discuss the latest research articles about hAHN and what their findings imply for the neurogenesis field.

摘要

对于成体海马神经发生(AHN)的研究而言,当下是令人兴奋的时期。关于成体甚至患病人类大脑中是否产生新神经元的争论和争议不断,支持和反对的文章日益增多。人类大脑中的成体神经发生是一种不符合量子力学特性的现象。科学界应该明确人类AHN是存在还是不存在,而不能同时认定两者皆成立。在这篇评论中,我们讨论了关于人类AHN的最新研究文章,以及它们的发现对神经发生领域意味着什么。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1b6/6727861/d777e2b71df0/fnins-13-00923-g001.jpg

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