Alizai Hamza, Walter William, Khodarahmi Iman, Burke Christopher J
Department of Radiology, NYU Langone Health, New York, New York.
Texas Scottish Rite Hospital for Children, Dallas, Texas.
Semin Musculoskelet Radiol. 2019 Oct;23(5):569-578. doi: 10.1055/s-0039-1695720. Epub 2019 Sep 25.
Osteoarthritis (OA) is the most common joint disease in the United States. The prevalence of OA is rising due to an aging population and increasing rates of obesity. Magnetic resonance imaging (MRI) allows an incomparable noninvasive assessment of all joint structures. Irreversible and progressive degradation of the articular cartilage remains the hallmark feature of OA. To date, attempts at developing disease-modifying drugs or biomechanical interventions for treating OA have proven unsuccessful. MRI-based cartilage imaging techniques have continued to advance, however, and will likely play a central role in the development of these joint preservation methods of the future. In this narrative review, we describe clinical MR image acquisition and assessment of cartilage. We discuss the semiquantitative cartilage scoring methods used in research. Lastly, we review the quantitative MRI techniques that allow assessment of changes in the biochemical composition of cartilage, even before the morphological changes are evident.
骨关节炎（OA）是美国最常见的关节疾病。由于人口老龄化和肥胖率上升，OA的患病率正在增加。磁共振成像（MRI）能够对所有关节结构进行无与伦比的非侵入性评估。关节软骨的不可逆和进行性退化仍然是OA的标志性特征。迄今为止，开发用于治疗OA的疾病修饰药物或生物力学干预措施的尝试均已失败。然而，基于MRI的软骨成像技术不断进步，很可能在未来这些关节保护方法的开发中发挥核心作用。在这篇叙述性综述中，我们描述了临床MR图像采集和软骨评估。我们讨论了研究中使用的半定量软骨评分方法。最后，我们回顾了定量MRI技术，这些技术能够在形态学变化明显之前评估软骨生化组成的变化。
