Manchi Melissa, Canzonieri Vincenzo
Pathology Unit, CRO Aviano IRCCS National Cancer Institute and University of Trieste, Trieste, Italy.
Pol J Pathol. 2019;70(1):26-32. doi: 10.5114/pjp.2019.84459.
The distinction between atypical Spitz lesions, conventional melanocytic nevi including Spitz nevi, and malignant melanomas may be difficult in some cases or may even be impossible. The histological assessment of these lesions is necessary to ensure correct diagnosis and treatment. Nevertheless, pathologists may be subject to suboptimal concordance in the diagnosis of some atypical lesions. In literature, certain atypical lesions have been defined differently: the terms atypical and metastasising Spitz tumour, malignant Spitz nevus, borderline and intermediate melanocytic tumour, melanocytic tumour of uncertain malignant potential MELTUMP, and low-grade malignant melanoma have been introduced to designate this heterogeneous group of pathological entities and variants. This review focuses on some issues concerning the historical background, diagnostic state-of-the-art, evolution, and classification of these complicated lesions.
在某些情况下，非典型斯皮茨病变、包括斯皮茨痣在内的传统黑素细胞痣与恶性黑色素瘤之间的区分可能很困难，甚至可能无法区分。对这些病变进行组织学评估对于确保正确的诊断和治疗是必要的。然而，病理学家在某些非典型病变的诊断中可能存在不太理想的一致性。在文献中，某些非典型病变的定义有所不同：非典型和转移性斯皮茨肿瘤、恶性斯皮茨痣、交界性和中间性黑素细胞肿瘤、恶性潜能不确定的黑素细胞肿瘤（MELTUMP）以及低级别恶性黑色素瘤等术语已被引入，以指代这一异质性的病理实体和变体组。本综述重点关注有关这些复杂病变的历史背景、诊断现状、演变及分类的一些问题。
