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Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients.

作者信息

Frerichs Kristine A, Bosman Patricia W C, van Velzen Jeroen F, Fraaij Pieter L A, Koopmans Marion P G, Rimmelzwaan Guus F, Nijhof Inger S, Bloem Andries C, Mutis Tuna, Zweegman Sonja, van de Donk Niels W C J

机构信息

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam.

University Medical Center, Laboratory of Translational Immunology, Utrecht.

出版信息

Haematologica. 2020 Jun;105(6):e302-e306. doi: 10.3324/haematol.2019.231860. Epub 2019 Sep 26.

DOI:10.3324/haematol.2019.231860
PMID:31558675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7271608/
Abstract
摘要

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Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study.硼替佐米、沙利度胺和地塞米松联合或不联合达雷妥尤单抗用于新诊断多发性骨髓瘤患者自体造血干细胞移植前后(CASSIOPEIA):一项随机、开放标签、3 期研究。
Lancet. 2019 Jul 6;394(10192):29-38. doi: 10.1016/S0140-6736(19)31240-1. Epub 2019 Jun 3.
2
Daratumumab plus lenalidomide and dexamethasone lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX.达雷妥尤单抗联合来那度胺和地塞米松 vs. 来那度胺和地塞米松治疗复发或难治性多发性骨髓瘤:POLLUX 更新分析。
Haematologica. 2018 Dec;103(12):2088-2096. doi: 10.3324/haematol.2018.194282. Epub 2018 Sep 20.
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The effect of immunosuppressive agents on immunogenicity of pneumococcal vaccination: A systematic review and meta-analysis.免疫抑制剂对肺炎球菌疫苗免疫原性的影响:系统评价和荟萃分析。
Vaccine. 2018 Sep 18;36(39):5832-5845. doi: 10.1016/j.vaccine.2018.07.039. Epub 2018 Aug 16.
4
Revaccination after Autologous Hematopoietic Stem Cell Transplantation Is Safe and Effective in Patients with Multiple Myeloma Receiving Lenalidomide Maintenance.自体造血干细胞移植后接受来那度胺维持治疗的多发性骨髓瘤患者进行再接种是安全有效的。
Biol Blood Marrow Transplant. 2018 Apr;24(4):871-876. doi: 10.1016/j.bbmt.2017.12.795. Epub 2017 Dec 27.
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Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab.在接受达雷妥尤单抗治疗的患者中,单核细胞和粒细胞降低骨髓瘤细胞上 CD38 的表达水平。
Clin Cancer Res. 2017 Dec 15;23(24):7498-7511. doi: 10.1158/1078-0432.CCR-17-2027. Epub 2017 Oct 12.
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Clinical and Serologic Responses After a Two-dose Series of High-dose Influenza Vaccine in Plasma Cell Disorders: A Prospective, Single-arm Trial.浆细胞疾病患者接种两剂高剂量流感疫苗后的临床和血清学反应:一项前瞻性单臂试验
Clin Lymphoma Myeloma Leuk. 2017 May;17(5):296-304.e2. doi: 10.1016/j.clml.2017.02.025. Epub 2017 Mar 7.
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Clin Pharmacokinet. 2017 Aug;56(8):915-924. doi: 10.1007/s40262-016-0477-1.
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Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.Daratumumab 单药治疗多发性骨髓瘤中针对 CD38。
N Engl J Med. 2015 Sep 24;373(13):1207-19. doi: 10.1056/NEJMoa1506348. Epub 2015 Aug 26.
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Efficacy of single versus boost vaccination against influenza virus in patients with multiple myeloma.多发性骨髓瘤患者中流感病毒单剂量疫苗与加强疫苗接种的效果比较
Haematologica. 2015 Jul;100(7):e285-8. doi: 10.3324/haematol.2014.116772. Epub 2015 Mar 27.
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Serum antibody response to influenza virus vaccination during chemotherapy treatment in adult patients with solid tumours.成人实体瘤患者化疗期间接种流感病毒疫苗的血清抗体反应。
Vaccine. 2013 Dec 16;31(52):6177-84. doi: 10.1016/j.vaccine.2013.10.053. Epub 2013 Oct 29.