Krasavin M Yu, Gureev M A, Garabadzhiu A V, Pashkin A Yu, Zhukov A S, Khairutdinov V R, Samtsov A V, Shvets V I
St. Petersburg State University, 199034, St. Petersburg, Russia.
St. Petersburg State Technological Institute (Technical University), 190013, St. Petersburg, Russia.
Dokl Biochem Biophys. 2019 Jul;487(1):272-276. doi: 10.1134/S1607672919040082. Epub 2019 Sep 26.
Psoriasis therapy remains an extremely relevant area of modern drug design, due to necessity of adverse reaction reduction, inherent for actual methods of therapy. It was established that two serine proteases-neutrophil elastase 1 (HNE1) and cathepsin G (CatG)-are the key agents in psoriasis development. The collected molecular data for the presented targets form the basis for the molecular modeling strategy for the search for and identification of new target-specific inhibitors. The result of this work is a group of high-priority small-molecule compounds with double-targeted affinity, which are able to suppress the pro-psoriatic processes induced by the considered serine proteases at the initial stage of the disease.
由于当前治疗方法存在不良反应减少的必要性，银屑病治疗仍然是现代药物设计中一个极其重要的领域。已经确定两种丝氨酸蛋白酶——中性粒细胞弹性蛋白酶1（HNE1）和组织蛋白酶G（CatG）——是银屑病发展的关键因素。为所提出的靶点收集的分子数据构成了寻找和鉴定新的靶点特异性抑制剂的分子建模策略的基础。这项工作的结果是一组具有双靶点亲和力的高优先级小分子化合物，它们能够在疾病初期抑制由所考虑的丝氨酸蛋白酶诱导的银屑病前期过程。
