钌催化二醇与伯胺的无受体脱氢偶联合成 N-取代内酰胺。
Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines.
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.
出版信息
Chem Commun (Camb). 2019 Oct 10;55(82):12384-12387. doi: 10.1039/c9cc06339k.
PMID:31559990
Abstract
Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.
摘要
在此，我们报告了首例通过二醇与伯胺在一步中进行无受体脱氢偶联合成 N-取代内酰胺的实例，该反应是通过将 Ru3(CO)12 与杂 N-杂环卡宾-膦-膦配体结合作为催化剂来实现的。
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