Zou You-Quan, Zhou Quan-Quan, Diskin-Posner Yael, Ben-David Yehoshoa, Milstein David
Department of Organic Chemistry, Weizmann Institute of Science Rehovot 76100 Israel
Chemical Research Support, Weizmann Institute of Science Rehovot 76100 Israel.
Chem Sci. 2020 Jun 22;11(27):7188-7193. doi: 10.1039/d0sc02065f.
A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction is also accomplished using the same catalyst. A plausible reaction mechanism is proposed based on stoichiometric reactions, NMR studies, X-ray crystallography as well as observation of plausible intermediates.
本文介绍了一种可持续的草酰胺新合成方法，该方法通过乙二醇与胺的无受体脱氢偶联反应生成氢气，由钌钳形配合物均相催化。使用相同的催化剂也能实现逆氢化反应。基于化学计量反应、核磁共振研究、X射线晶体学以及对可能中间体的观察，提出了一种合理的反应机理。
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