miR-188-5p 和 miR-141-3p 影响膀胱癌的预后，并协同促进膀胱癌的发生。
MiR-188-5p and MiR-141-3p influence prognosis of bladder cancer and promote bladder cancer synergistically.
机构信息
China Medical University, Shenyang 110013, China; The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China.
The Fourth Affiliated Hospital of China Medical University, Shenyang 110122, China.
出版信息
Pathol Res Pract. 2019 Nov;215(11):152598. doi: 10.1016/j.prp.2019.152598. Epub 2019 Aug 17.
MicroRNA (miRNA) plays a significant role in suppressing the occurrence and development of tumor by inhibiting the translation of target proteins. Although previous researches have verified many miRNAs' functions in bladder cancer (BC), the function of miR-188-5p and miR-141-3p in BC still remains unknown. Our experiment manifested that miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells, which indicated a poor prognosis. In vitro functional assays suggested that down-regulated miR-188-5p and miR-141-3p inhibited the proliferation, migration and invasion of BC cells, while a combination of half dose down-regulated miR-188-5p and half dose down-regulated miR-141-3p demonstrated a more obvious inhibition effect. All results indicated that miR-188-5p and miR-141-3p promoted BC respectively and synergistically. Therefore, miR-188-5p and miR-141-3p will not only assist the diagnosis of BC, but also serve as more effective joint markers to predict the progression of BC.
微小 RNA（miRNA）通过抑制靶蛋白的翻译在抑制肿瘤的发生和发展中发挥重要作用。虽然先前的研究已经验证了许多 miRNA 在膀胱癌（BC）中的功能，但 miR-188-5p 和 miR-141-3p 在 BC 中的功能仍不清楚。我们的实验表明，miR-188-5p 和 miR-141-3p 在 BC 组织和细胞中高表达，提示预后不良。体外功能测定表明，下调 miR-188-5p 和 miR-141-3p 抑制了 BC 细胞的增殖、迁移和侵袭，而半剂量下调 miR-188-5p 和半剂量下调 miR-141-3p 的组合表现出更明显的抑制作用。所有结果表明，miR-188-5p 和 miR-141-3p 分别促进了 BC 的发展，并具有协同作用。因此，miR-188-5p 和 miR-141-3p 不仅有助于 BC 的诊断，而且还可以作为更有效的联合标志物来预测 BC 的进展。
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