Eldridge S A, Hilton F K, Hilton M A
J Exp Zool. 1985 Jan;233(1):139-41. doi: 10.1002/jez.1402330120.
The effects of hypoxic hypoxia on the concentration of taurine in right ventricles was studied in the hearts of male CF1 mice caged individually and maintained for 16 hr per day in a hypobaric chamber evacuated to an air pressure of 307 mm Hg. After 23 days hearts were excised and right and left ventricles were separated and lyophilized. Hematocrits in chamber animals were 77-82%, compared to 45-49% for control mice. Mean weights of right ventricles of animals from the chamber were 11.2 +/- 0.9, compared to control values of 7.0 +/- 0.4, mg dry weight. The mean dry weights of left ventricles in both groups of animals were the same. There were no significant differences in the nmoles taurine per mg day tissue in either heart chamber, with mean values +/- S.E.M. of 124.0 +/- 4.6 and 135.0 +/- 4.5 in right ventricles and 128.0 +/- 4.3 and 110.9 +/- 15.3 in left ventricles of experimental and control animals respectively. Thus, hypertrophy which results from hypoxia is not accompanied by increased concentrations of taurine in right ventricles.
在单独饲养的雄性CF1小鼠心脏中，研究了低氧性缺氧对右心室中牛磺酸浓度的影响。这些小鼠每天在抽空至气压为307毫米汞柱的低压舱中饲养16小时。23天后，取出心脏，分离右心室和左心室并冻干。舱内动物的血细胞比容为77 - 82%，而对照小鼠为45 - 49%。舱内动物右心室的平均干重为11.2±0.9毫克，而对照值为7.0±0.4毫克干重。两组动物左心室的平均干重相同。两个心腔中每毫克组织每天的牛磺酸纳摩尔数没有显著差异，实验组和对照组动物右心室的平均值±标准误分别为124.0±4.6和135.0±4.5，左心室分别为128.0±4.3和110.9±15.3。因此，由缺氧引起的肥大并不伴随着右心室中牛磺酸浓度的增加。
