Gul Zeynep, Chughtai Bilal, Te Alexis E, Thomas Dominique, Kaplan Steven A
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Urology, Weill Cornell Medical College-New York Presbyterian, New York, NY.
Urology. 2019 Dec;134:199-202. doi: 10.1016/j.urology.2019.07.042. Epub 2019 Sep 26.
To report long-term safety and efficacy data on middle lobe only-transurethral resection of the prostate (TURP) (MLO-TURP).
We evaluated: (1) efficacy: International Prostate Symptom Score, Quality of Life, peak flow rate (Qmax), postvoid residual urine, International Index of Erectile Function and ejaculatory function, which was assessed by the Male Sexual Health Questionnaire. Men were evaluated at 1 month, 6 months, and yearly thereafter.
A total 312 men (mean age 61.3 ± 8.6) with significant lower urinary tract symptoms (n = 147) or urinary retention (n = 175 were treated with MLO-TURP from 2005 to 2017. Mean baseline prostate volume was 79.8 g (30-178 g); mean baseline intravesical-prostatic protrusion was 13.6. Improvements in International Prostate Symptom Score, Quality of Life, Qmax and postvoid residual urine were durable throughout the study period. There was no difference in outcomes between monopolar and bipolar MLO-TURPs. Postoperatively, the incidence of ejaculatory dysfunction was 2.6% (N = 8) and there was 1 case of new onset ED (0.3%). There were modest improvement in bother due to ejaculatory function (baseline: 2.4 and at 5 years: 1.27).
MLO-TURP is a safe and effective treatment for men with lower urinary tract symptoms. Patients experience long-term improvement of symptoms and preserve antegrade ejaculation. In select men with prominent middle lobes, MLO-- should be considered a therapeutic, ejaculation-sparing option.
报告仅针对中叶的经尿道前列腺切除术(MLO-TURP)的长期安全性和疗效数据。
我们评估了:(1)疗效:国际前列腺症状评分、生活质量、最大尿流率(Qmax)、排尿后残余尿量、国际勃起功能指数和射精功能,后者通过男性性健康问卷进行评估。男性在术后1个月、6个月进行评估,此后每年评估一次。
2005年至2017年,共有312名男性(平均年龄61.3±8.6岁)接受了MLO-TURP治疗,其中147名有明显下尿路症状,175名有尿潴留。平均基线前列腺体积为79.8 g(30 - 178 g);平均基线膀胱内前列腺突出度为13.6。在整个研究期间,国际前列腺症状评分、生活质量、Qmax和排尿后残余尿量均持续改善。单极和双极MLO-TURP的治疗效果无差异。术后射精功能障碍的发生率为2.6%(N = 8),新发勃起功能障碍1例(0.3%)。射精功能所致困扰有适度改善(基线:2.4,5年后:1.27)。
MLO-TURP是治疗下尿路症状男性的一种安全有效的方法。患者症状得到长期改善,且能保留顺行射精功能。对于中叶突出的特定男性患者,MLO-TURP应被视为一种保留射精功能的治疗选择。