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免疫功能正常儿童的孤立性脾结核:一例报告

Solitary Splenic Tuberculosis in an Immunocompetent Child: A Case Report.

作者信息

Metlo Assadullah, Shah Sm Ismail, Rehan Aiman, Bin Waqar Syed Hamza, Siddiqi Rabbia

机构信息

Pediatrics, Civil Hospital, Karachi, PAK.

Internal Medicine, Ziauddin Medical College, Karachi, PAK.

出版信息

Cureus. 2019 Jul 23;11(7):e5210. doi: 10.7759/cureus.5210.

Abstract

Tuberculosis (TB) is a lethal infectious disease that still remains a major threat in developing countries. Solitary splenic tuberculosis is a rare entity and there have been very few cases of it reported in literature. It is mostly encountered in patients who have an immunocompromised state. It may occur with a myriad of non-specific presentations, making it complex to diagnose. Here, we report a case of an eight-year-old female, immunocompetent, who had complaints of fever, abdominal pain and chronic diarrhea. Laboratory data failed to provide any information about the final diagnosis. On physical examination, splenomegaly was present. Imaging studies were conducted with an abdominal ultrasound showcasing mild ascites, splenomegaly, with a homogeneous echo pattern and no focal mass. Computed tomography (CT) of the abdomen showed two hypodense areas in the subcapsular region of the spleen and extending into the capsule, suggestive of a tuberculous abscess with mesenteric lymphadenopathy. The diagnosis was further corroborated when the patient showed remarkable improvement on anti-tuberculous therapy. This is a very uncommon phenomenon, especially in an immunocompetent patient and hence, it is very important to keep this on the list of differentials especially in an area where TB is endemic.

摘要

结核病是一种致命的传染病,在发展中国家仍然是一个重大威胁。孤立性脾结核是一种罕见的疾病,文献中报道的病例很少。它主要见于免疫功能低下的患者。它可能以多种非特异性表现出现,使其诊断变得复杂。在此,我们报告一例8岁免疫功能正常的女性病例,她有发热、腹痛和慢性腹泻的症状。实验室数据未能提供任何有关最终诊断的信息。体格检查发现脾肿大。进行了腹部超声检查,显示有少量腹水、脾肿大,回声均匀,无局灶性肿块。腹部计算机断层扫描(CT)显示脾脏包膜下区域有两个低密度区并延伸至包膜,提示结核性脓肿伴肠系膜淋巴结肿大。当患者在抗结核治疗后有明显改善时,诊断得到进一步证实。这是一种非常罕见的现象,尤其是在免疫功能正常的患者中,因此,在结核病流行地区,将其列入鉴别诊断清单非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5ae/6758994/016dca303c0b/cureus-0011-00000005210-i01.jpg

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