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免疫功能正常患者的孤立性脾结核:一例罕见病例报告

Isolated spleen tuberculosis in an immunocompetent patient, a rare case report.

作者信息

Lestari Diah Asih, Rahadiani Nur, Syaiful Ridho Ardhi

机构信息

Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat 10430, Indonesia.

Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jl Diponegoro No 71, Salemba, Jakarta Pusat 10430, Indonesia.

出版信息

Int J Surg Case Rep. 2021 Jun;83:105966. doi: 10.1016/j.ijscr.2021.105966. Epub 2021 May 12.

Abstract

INTRODUCTION

Tuberculosis (TB), as a major public health concern, is affecting almost 10 million people globally. At present, diagnostic and screening efforts mainly focus on positive smear results. Therefore, the number of extra pulmonary and negative sputum TB is rising and hampering the diagnosis and treatment process due to the large number of false negatives. Rare cases such as solitary splenic TB are usually seen in patients with splenic abnormalities, spleen trauma, immunosuppression, sickle cell disease, pyogenic infections, etc. PRESENTATION OF CASE: A 40-year-old female with no comorbidity came with chief complaint of early satiety every mealtime and epigastric pain in the last 6 months prior to admission. There was no significant positive examination except for positive IGRA test and enlargement of spleen with multiple cystic lesions on abdominal CT. We performed laparotomy with splenectomy followed by a histopathology examination which showed features of primary tubercular abscess.

DISCUSSION

In the immunocompromised patient, the visceral abdomen is usually involved and a part of miliary TB. However, this case revealed the rare possibility of a healthy person with primary isolated tubercular splenic abscess while being immunocompetent and lacking any comorbidity.

CONCLUSION

Splenic TB diagnosis is difficult in patients lacking pulmonary involvement and without specific symptoms. Thorough examinations and clinical expertise are needed to provide accurate diagnosis and treat uncommon forms of TB and cases with negative smear results in consideration of rising prevalence and difficult disease control.

摘要

引言

结核病作为一个主要的公共卫生问题,正在影响全球近1000万人。目前,诊断和筛查工作主要集中在涂片阳性结果上。因此,肺外结核和痰菌阴性结核的数量正在上升,由于大量假阴性结果,这阻碍了诊断和治疗进程。孤立性脾结核等罕见病例通常见于有脾异常、脾外伤、免疫抑制、镰状细胞病、化脓性感染等的患者。

病例介绍

一名40岁无合并症女性,入院前6个月每餐均有早饱感和上腹部疼痛为主诉前来就诊。除IGRA检测阳性和腹部CT显示脾脏肿大伴多发囊性病变外,无明显阳性检查结果。我们进行了剖腹脾切除术,随后进行组织病理学检查,结果显示为原发性结核脓肿特征。

讨论

在免疫功能低下的患者中,腹部脏器通常会受累,是粟粒性结核的一部分。然而,该病例显示了一个健康人在免疫功能正常且无任何合并症的情况下发生原发性孤立性结核性脾脓肿的罕见可能性。

结论

在缺乏肺部受累且无特异性症状的患者中,脾结核的诊断较为困难。考虑到发病率上升和疾病控制困难,需要进行全面检查和临床专业知识来提供准确诊断,并治疗不常见形式的结核病和涂片阴性病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e81a/8175403/f273ebe7ec2c/gr1.jpg

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