钠对[3H]-硝苯地平与心肌膜结合的干扰。
Interference of sodium with [3H]-nitrendipine binding to cardiac membranes.
作者信息
Schwartz J, Velly J
出版信息
Br J Pharmacol. 1985 Feb;84(2):511-5. doi: 10.1111/j.1476-5381.1985.tb12935.x.
Abstract
Interference of sodium with [3H]-nitrendipine binding was studied on membrane homogenates from guinea-pig skeletal muscle, cerebral cortex and left cardiac ventricle. [3H]-nitrendipine binding on homogenates from cerebral cortex and skeletal muscle was unaffected by Na+ (35 and 140 mEql(-1]. On the other hand, for the myocardial receptors, addition of Na+ resulted in an increase in IC50 of nitrendipine. Simultaneously, for the myocardial preparations, saturation curves showed a decrease in [3H]-nitrendipine affinity and an increase in the number of binding sites.
摘要
研究了钠对豚鼠骨骼肌、大脑皮层和左心室肌膜匀浆中[3H]-尼群地平结合的干扰作用。大脑皮层和骨骼肌匀浆中的[3H]-尼群地平结合不受Na+（35和140 mEql(-1）的影响。另一方面，对于心肌受体，添加Na+导致尼群地平的IC50增加。同时，对于心肌制剂，饱和曲线显示[3H]-尼群地平亲和力降低，结合位点数量增加。
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Arzneimittelforschung. 1981;31(12):2064-7.
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3
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4
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5
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