Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany; email:
Annu Rev Virol. 2019 Sep 29;6(1):1-28. doi: 10.1146/annurev-virology-092818-015907.
This review briefly covers periods of my early life; experiences during World War II; my school education; and my period as a medical student in Bonn, Hamburg, and Düsseldorf. Mainly emphasized is my scientific career after finishing my medical internship and periods as a postdoc at the Institute for Microbiology in Düsseldorf and the Virus Laboratories of the Children's Hospital of Philadelphia and as Senior Research Fellow at the Institute of Virology in Würzburg, Germany. Subsequent appointment as chairman of the newly established Institute of Virology, University of Erlangen-Nürnberg, in a similar position at the University of Freiburg, and then for 20 years as scientific director of the Deutsches Krebsforschungszentrum, Heidelberg, are discussed, covering the scientific developments during these periods. The emeritus period since 2003 was particularly exciting, leading to the discovery of autonomously replicating plasmids, derived from specific bacteria, and their link to common human cancers (colon, breast, and prostate).
本文简要回顾了我的早年生活经历、二战期间的经历、学校教育以及在波恩、汉堡和杜塞尔多夫的医学生涯。重点介绍了我完成住院实习后的科学生涯，以及在杜塞尔多夫微生物研究所、费城儿童医院病毒实验室担任博士后研究员和在德国维尔茨堡病毒研究所担任高级研究员的经历。随后，我在新成立的埃尔朗根-纽伦堡大学病毒研究所担任主席，在弗赖堡大学担任类似职务，之后 20 年担任海德堡德国癌症研究中心的科学主任，讨论了在此期间的科学发展。自 2003 年退休以来，我一直非常兴奋，发现了源自特定细菌的自主复制质粒及其与常见人类癌症（结肠癌、乳腺癌和前列腺癌）的联系。
