人类疱疹病毒 6 与移植受者：诊断和治疗策略的最新进展。
Human herpesvirus 6 in transplant recipients: an update on diagnostic and treatment strategies.
机构信息
Vaccine and Infectious Disease Division.
Clinical Research Division, Fred Hutchinson Cancer Research Center.
出版信息
Curr Opin Infect Dis. 2019 Dec;32(6):584-590. doi: 10.1097/QCO.0000000000000592.
Abstract
PURPOSE OF REVIEW
The current review article focuses on recent advances in the approach to the diagnosis and treatment of human herpesvirus 6B (HHV-6B) in hematopoietic cell and solid organ transplant recipients.
RECENT FINDINGS
Over the past few years, key studies have broadened our understanding of best practices for the prevention and treatment of HHV-6B encephalitis after transplantation. Moreover, important data have been reported that support a potential role of HHV-6B reactivation in the development of acute graft-versus-host disease and lower respiratory tract disease in transplant recipients. Finally, increasing recognition of inherited chromosomally integrated HHV-6 (iciHHV-6) and an expanding array of diagnostic tools have increased our understanding of the potential for complications related to viral reactivation originating from iciHHV-6 in donors or recipients.
SUMMARY
Recent advances in diagnostic tools, disease associations, and potential treatments for HHV-6B present abundant opportunities for improving our understanding and management of this complex virus in transplant recipients.
摘要
目的综述
本文重点介绍造血细胞和实体器官移植受者中人类疱疹病毒 6B（HHV-6B）的诊断和治疗方法的最新进展。
最近的发现
在过去的几年中，一些重要研究拓宽了我们对预防和治疗移植后 HHV-6B 脑炎的最佳方法的理解。此外，已有重要数据表明 HHV-6B 再激活可能与移植受者急性移植物抗宿主病和下呼吸道疾病的发生有关。最后，人们越来越认识到染色体整合的人类疱疹病毒 6（iciHHV-6）和不断扩展的诊断工具阵列，这增加了我们对供体或受体内源性病毒再激活相关并发症的理解。
总结
HHV-6B 的诊断工具、疾病相关性和潜在治疗方法的最新进展为改善我们对移植受者中这种复杂病毒的理解和管理提供了丰富的机会。
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