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使用骨水泥间隔物治疗的肱骨近端转移瘤患者的生活质量

Quality of life of patients with proximal humerus metastasis treated with cement spacer.

作者信息

Guo Wen, Gao Xin, Wang Dongsheng, Wang Tao, Tang Liang, Wang Yao, Liu Bin

机构信息

Department of Orthopedics, Taizhou People's Hospital, Taizhou 225300, Jiangsu, People's Republic of China.

Orthopaedic Oncology Center, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai 200000, People's Republic of China.

出版信息

Cancer Manag Res. 2019 Sep 17;11:8499-8506. doi: 10.2147/CMAR.S219178. eCollection 2019.

Abstract

PURPOSE

The goal of this study was to determine whether the surgery using cement spacer could improve the quality of life of patients with proximal humerus metastasis.

PATIENTS AND METHODS

This is a retrospective study. The study included 34 patients who had been treated for proximal humerus metastasis between January 2010 and June 2014. The patients were divided into surgical and non-surgical group depending on whether they underwent cement spacer surgery. The patient's quality of life (QOL) assessment is scheduled at five points-at the initial diagnosis (baseline) and at 1 month, 3 months, 6 months, and 9 months of follow-up. Evaluation tool is Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire.

RESULTS

A total of 34 patients, including 15 patients in the surgery group and 19 patients in the non-surgery group, were enrolled in this retrospective study. In the end, 22 patients finished all evaluations, including 11 patients in the surgical group and 11 patients in the non-surgery group. At the completion of the study, 22 patients had died, including 8 patients in the surgery group and 14 patients in the non-surgery group. After surgical using the cement spacer, the QOL scores of patients at each follow-up point were significantly higher than that of preoperative scores. These scores were also higher than those of the non-surgery group.

CONCLUSION

The current study indicated that surgical treatment using the cement spacer could upgrade and maintain quality of life for patients with proximal humerus metastasis in the 9-month assessment.

摘要

目的

本研究的目的是确定使用骨水泥间隔物的手术是否能改善肱骨近端转移患者的生活质量。

患者与方法

这是一项回顾性研究。该研究纳入了2010年1月至2014年6月期间接受肱骨近端转移治疗的34例患者。根据患者是否接受骨水泥间隔物手术,将其分为手术组和非手术组。在初始诊断(基线)以及随访的1个月、3个月、6个月和9个月这五个时间点对患者的生活质量(QOL)进行评估。评估工具为癌症治疗功能评估通用版(FACT-G)问卷。

结果

本回顾性研究共纳入34例患者,其中手术组15例,非手术组19例。最终,22例患者完成了所有评估,其中手术组11例,非手术组11例。在研究结束时,22例患者死亡,其中手术组8例,非手术组14例。使用骨水泥间隔物进行手术后,各随访点患者的QOL评分均显著高于术前评分。这些评分也高于非手术组。

结论

当前研究表明,在9个月的评估中,使用骨水泥间隔物的手术治疗可提升并维持肱骨近端转移患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec76/6756156/599e52003bba/CMAR-11-8499-g0001.jpg

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