Daniele S, Frati L, Fiore C, Santoni G
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 May 7;210(3):159-65. doi: 10.1007/BF00414564.
Epidermal growth factor (EGF) is a polypeptide hormone present in mammalian organs. In vivo, it shortens the time course of the corneal reepithelialization by stimulating a marked cell proliferation of the corneal epithelium. A further direct effect in vivo has been confirmed on human corneal epithelium and epidermis in culture. Tests in several nondystrophic diseases of the corneal epithelium confirmed the observations previously made in the rabbit that EGF accelerates the process of epithelial healing. The integrity of the corneal stroma is prejudicial for the maximum effect of the EGF, in the sense that the deeper the stroma is damaged, the less EGF acts. In herpetic lesions EGF is effective within 48 h only when the virus-affected area of the corneal epithelium has been scraped off. EGF is proposed as a new and efficacious agent for increasing the restorative process of the corneal epithelium in many nondystrophic diseases.
表皮生长因子（EGF）是一种存在于哺乳动物器官中的多肽激素。在体内，它通过刺激角膜上皮细胞显著增殖来缩短角膜再上皮化的时间进程。对培养的人角膜上皮和表皮的体内进一步直接作用已得到证实。在几种非营养不良性角膜上皮疾病中的测试证实了先前在兔子身上的观察结果，即EGF可加速上皮愈合过程。角膜基质的完整性对EGF的最大作用是不利的，从某种意义上说，基质损伤越深，EGF的作用越小。在疱疹性病变中，只有当角膜上皮的病毒感染区域被刮除时，EGF才在48小时内有效。EGF被提议作为一种新的有效药物，用于促进许多非营养不良性疾病中角膜上皮的修复过程。
