Stockley R A, Burnett D
Am Rev Respir Dis. 1979 Nov;120(5):1081-6. doi: 10.1164/arrd.1979.120.5.1081.
Leukocyte elastase and alpha 1-antitrypsin have been implicated in the pathogenesis of pulmonary emphysema. The relationship between these proteins has been studied in sputum both qualitatively and quantitatively in bronchitic patients with and without chest infections. Leukocyte elastase was found in 75% of the noninfected samples but was enzymatically inactive, suggesting complete inhibition. During infection, leukocyte elastase and alpha 1-antitrypsin concentrations increased, although the enzyme was only partially inactivated. The proportion of alpha 1-antitrypsin present as "complex" was smaller in the presence of infection, suggesting damage of the protein by excess enzyme.
白细胞弹性蛋白酶和α1抗胰蛋白酶与肺气肿的发病机制有关。在有和没有胸部感染的支气管炎患者的痰液中，对这些蛋白质之间的关系进行了定性和定量研究。在75%的未感染样本中发现了白细胞弹性蛋白酶，但该酶无酶活性，提示完全抑制。在感染期间，白细胞弹性蛋白酶和α1抗胰蛋白酶浓度增加，尽管该酶仅部分失活。在有感染的情况下，以“复合物”形式存在的α1抗胰蛋白酶比例较小，提示蛋白质被过量酶破坏。
