Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; Clinical Neurophysiology Unit, San Salvatore Hospital, L'Aquila, Italy.
Department of Mental Health, ASL1, L'Aquila, Italy.
Epilepsy Behav. 2019 Nov;100(Pt A):106383. doi: 10.1016/j.yebeh.2019.06.027. Epub 2019 Sep 28.
Persons with epilepsy show a higher risk of suicidal ideation and behavior than the general population. Hopelessness, as a feature of demoralization, is considered an emerging risk factor for suicidal ideation. Psychopathological comorbidity, mainly depression, has to be taken into account to predict suicidal attempts but the relationship between suicidality and epilepsy has been also reported independently from depressive disorders. The aim of the study was to investigate hopelessness in a sample of persons suffering from epilepsy without comorbidity with psychiatric disorders and its association with demographic, social, and clinical variables, putatively predictive of suicidal behaviors. Beck Hopelessness Scale (BHS) has been used as measure of suicidal ideation in 72 consecutive outpatients afferent to a third level epilepsy center. Exclusion criterion was psychiatric comorbidity evaluated by clinical approach and quantified by Clinical Global Impression (CGI) Scale. Clinical (focus localization, age at onset, number of drugs), demographic, social variables, and intellectual level were considered. Age, age at onset, gender, intellectual level, socioeconomic status, duration of illness and therapy, number of drugs, seizure frequency, and localization of the epileptic focus and side involved were found associated with BHS score increase. In a sample of persons with epilepsy, without psychiatric comorbidity, our data show an association between factors related to the biological pathophysiology and the clinical course of the disease with the sociodemographic status, as a risk factor for suicidal ideation.
癫痫患者的自杀意念和行为风险高于普通人群。绝望是颓废的一个特征，被认为是自杀意念的一个新出现的危险因素。需要考虑精神病理学共病，主要是抑郁症，以预测自杀企图，但自杀性与癫痫之间的关系也有报道，与抑郁障碍无关。本研究的目的是调查无精神障碍癫痫患者样本中的绝望情绪，及其与人口统计学、社会和临床变量的关系，这些变量可能预测自杀行为。贝克绝望量表（BHS）被用于评估 72 名连续就诊于三级癫痫中心的门诊患者的自杀意念。排除标准是通过临床方法评估的精神共病，并通过临床总体印象（CGI）量表进行量化。考虑了临床（焦点定位、发病年龄、药物种类）、人口统计学、社会变量和智力水平。年龄、发病年龄、性别、智力水平、社会经济地位、疾病和治疗持续时间、药物种类、癫痫发作频率以及癫痫灶和受累侧的定位与 BHS 评分增加有关。在无精神共病的癫痫患者样本中，我们的数据显示与疾病的生物学病理生理学和临床病程相关的因素与社会人口统计学状况之间存在关联，社会人口统计学状况是自杀意念的一个危险因素。
