Department of Respiratory Medicine, Ningbo No. 7 Hospital, Ningbo, China.
Department of Emergency Medicine, Ningbo No. 7 Hospital, Ningbo, China,
Int Arch Allergy Immunol. 2019;180(4):255-263. doi: 10.1159/000502522. Epub 2019 Oct 1.
In recent years, many studies have focused on the association between plasminogen activator inhibitor (PAI)-1 gene 4G/5G polymorphism and risk of allergic diseases, but the results have been inconclusive.
We conducted this meta-analysis to study the exact relationship between PAI-1 polymorphism and susceptibility to allergic diseases.
All eligible studies were determined by an electronic literature search. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association under all of the models.
A total of 14 studies involving 2,327 cases and 2,838 controls were included in this meta-analysis. Overall, we found a significant association between PAI-1 polymorphism and risk of allergic diseases (4G/4G + 4G/5G vs. 5G/5G: OR 1.76, 95% CI 1.39-2.22, p < 0.00001). In a subgroup analysis by ethnicity, we found a markedly increased risk in Asians (OR 1.62, 95% CI 1.26-2.09, p = 0.0002) and Caucasians (OR 1.78, 95% CI 1.26-2.52, p = 0.001). In addition, significant associations between PAI-1 polymorphism and risk of allergic diseases were observed in both adults (OR 1.71, 95% CI 1.23-2.38, p = 0.001) and children (OR 1.87, 95% CI 1.42-2.46, p < 0.00001). In a subgroup analysis by different allergic diseases, a significantly increased risk was found for asthma (OR 1.78, 95% CI 1.33-2.39, p = 0.001) but not for rhinitis (OR 1.51, 95% CI 0.79-2.89, p = 0.22).
This meta-analysis demonstrated that PAI-1 gene 4G/5G polymorphism was associated with an increased risk of allergic diseases.
近年来，许多研究集中于纤溶酶原激活物抑制剂（PAI）-1 基因 4G/5G 多态性与过敏性疾病风险之间的关联，但结果尚无定论。
我们进行了这项荟萃分析，以研究 PAI-1 多态性与过敏性疾病易感性的确切关系。
通过电子文献检索确定所有符合条件的研究。使用比值比（ORs）及其 95%置信区间（CIs）来评估所有模型下关联的强度。
这项荟萃分析共纳入了 14 项研究，包括 2327 例病例和 2838 例对照。总体而言，我们发现 PAI-1 多态性与过敏性疾病风险之间存在显著关联（4G/4G+4G/5G 与 5G/5G：OR 1.76，95%CI 1.39-2.22，p<0.00001）。按种族进行亚组分析时，我们发现亚洲人（OR 1.62，95%CI 1.26-2.09，p=0.0002）和高加索人（OR 1.78，95%CI 1.26-2.52，p=0.001）的风险显著增加。此外，我们还发现 PAI-1 多态性与过敏性疾病风险之间存在显著关联，无论是在成年人（OR 1.71，95%CI 1.23-2.38，p=0.001）还是儿童（OR 1.87，95%CI 1.42-2.46，p<0.00001）中。在不同过敏性疾病的亚组分析中，我们发现哮喘的风险显著增加（OR 1.78，95%CI 1.33-2.39，p=0.001），但鼻炎的风险没有增加（OR 1.51，95%CI 0.79-2.89，p=0.22）。
这项荟萃分析表明，PAI-1 基因 4G/5G 多态性与过敏性疾病的风险增加有关。
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