Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
PLoS One. 2012;7(3):e34385. doi: 10.1371/journal.pone.0034385. Epub 2012 Mar 27.
A number of studies assessed the association of -675 4G/5G polymorphism in the promoter region of plasminogen activator inhibitor (PAI)-1 gene with asthma in different populations. However, most studies reported inconclusive results. A meta-analysis was conducted to investigate the association between polymorphism in the PAI-1 gene and asthma susceptibility.
Databases including Pubmed, EMBASE, HuGE Literature Finder, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the dominant model, recessive model, codominant model, and additive model.
Eight studies involving 1817 cases and 2327 controls were included. Overall, significant association between 4G/5G polymorphism and asthma susceptibility was observed for 4G4G+4G5G vs. 5G5G (OR = 1.56, 95% CI 1.12-2.18, P = 0.008), 4G/4G vs. 4G/5G+5G/5G (OR = 1.38, 95% CI 1.06-1.80, P = 0.02), 4G/4G vs. 5G/5G (OR = 1.80, 95% CI 1.17-2.76, P = 0.007), 4G/5G vs. 5G/5G (OR = 1.40, 95% CI 1.07-1.84, P = 0.02), and 4G vs. 5G (OR = 1.35, 95% CI 1.08-1.68, P = 0.008).
This meta-analysis suggested that the -675 4G/5G polymorphism of PAI-1 gene was a risk factor of asthma.
许多研究评估了纤溶酶原激活物抑制剂（PAI-1）基因启动子区域的-675 4G/5G 多态性与不同人群哮喘之间的关联。然而，大多数研究的结果并不一致。进行了一项荟萃分析，以研究 PAI-1 基因多态性与哮喘易感性之间的关系。
检索了 Pubmed、EMBASE、HuGE Literature Finder、万方数据库、中国知网（CNKI）和维普数据库等数据库，以寻找相关研究。使用优势模型、隐性模型、共显性模型和加性模型的优势比（OR）和 95%置信区间（CI）来评估关联的强度。
共纳入 8 项研究，包括 1817 例病例和 2327 例对照。总体而言，4G/5G 多态性与哮喘易感性之间存在显著关联，4G4G+4G5G 与 5G5G 相比（OR=1.56，95%CI 1.12-2.18，P=0.008），4G/4G 与 4G/5G+5G/5G 相比（OR=1.38，95%CI 1.06-1.80，P=0.02），4G/4G 与 5G/5G 相比（OR=1.80，95%CI 1.17-2.76，P=0.007），4G/5G 与 5G/5G 相比（OR=1.40，95%CI 1.07-1.84，P=0.02），4G 与 5G 相比（OR=1.35，95%CI 1.08-1.68，P=0.008）。
这项荟萃分析表明，PAI-1 基因的-675 4G/5G 多态性是哮喘的一个危险因素。
