Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.
Mol Nutr Food Res. 2019 Dec;63(23):e1900626. doi: 10.1002/mnfr.201900626. Epub 2019 Oct 9.
Obesity is a chronic condition resulting in excessive fat accumulation in adipose tissues. Adipose tissue is now considered as an immune organ, at the crossroads between metabolism and immunity. Thus, this study investigates the effects of adzuki beans on obesity and gut microbiota in high fat diet-induced mice.
In this study, adzuki bean hot water extract (AWE) is determined to have the most significant anti-adipogenic effect; it is able to inhibit lipid accumulation in 3T3-L1 adipocytes and reduces body weight and adipose tissue weight in a dose-dependent manner. AWE treatment also decreases M1-polarized adipose tissue macrophages (ATMs) while inducing M2-polarized ATMs. The number and size of fat vacuoles in liver lesions are significantly reduced, indicating that AWE could ameliorate steatosis in high fat diet-induced mice. The results also demonstrate that AWE-treated groups inhibit adipogenesis via activating the Wnt/β-catenin pathway and reduce peroxisome proliferator-activated receptor gamma and CCAAT/enhancer binding proteins α expression. Moreover, the studies confirm that AWE decreases obesity through modulating gut microbiota.
The results demonstrate that AWE supplementation ameliorates high fat diet-induced obesity and gut microbiota composition and suggests that AWE may have the potential to be developed into a functional food to improve metabolic disorders.
肥胖是一种慢性病症，导致脂肪在脂肪组织中过度积累。脂肪组织现在被认为是一个免疫器官，处于代谢和免疫的交叉点。因此，本研究调查了红豆对高脂肪饮食诱导的肥胖和肠道微生物群的影响。
在这项研究中，确定红豆热水提取物（AWE）具有最显著的抗脂肪生成作用；它能够抑制 3T3-L1 脂肪细胞中的脂质积累，并以剂量依赖的方式降低体重和脂肪组织重量。AWE 处理还减少了 M1 极化的脂肪组织巨噬细胞（ATMs），同时诱导了 M2 极化的 ATMs。肝损伤中脂肪空泡的数量和大小明显减少，表明 AWE 可以改善高脂肪饮食诱导的小鼠的脂肪变性。结果还表明，AWE 通过激活 Wnt/β-catenin 途径抑制脂肪生成，并降低过氧化物酶体增殖物激活受体γ和 CCAAT/增强子结合蛋白α的表达。此外，研究证实 AWE 通过调节肠道微生物群来减轻肥胖。
结果表明，AWE 补充可改善高脂肪饮食诱导的肥胖和肠道微生物群组成，并表明 AWE 可能有潜力开发成功能性食品，以改善代谢紊乱。
