成纤维细胞生长因子3（FGF3）、成纤维细胞生长因子10（FGF10）和成纤维细胞生长因子13（FGF13）的多态性可能与需要正颌手术的患者颞下颌关节紊乱症的发生有关。

Polymorphisms in FGF3, FGF10, and FGF13 May Contribute to the Presence of Temporomandibular Disorders in Patients Who Required Orthognathic Surgery.

作者信息

Carpio Horta Karla, Weiss Suyany Gabriely, Miranda Katheleen, Sebastiani Aline Monise, Costa Delson João da, Matsumoto Mírian Aiko Nakane, Marañón-Vásquez Guido Artemio, Vieira Alexandre Rezende, Scariot Rafaela, Küchler Erika Calvano

机构信息

Department of Pediatric Dentistry, Orthodontic Area, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto.

Department of Dentistry, School of Health Science, Positivo University.

出版信息

J Craniofac Surg. 2019 Oct;30(7):2082-2084. doi: 10.1097/SCS.0000000000006029.

DOI:10.1097/SCS.0000000000006029

PMID:31574782

Abstract

BACKGROUND

To evaluate whether genetic polymorphisms in FGF3, FGF10, and FGF13 are associated with temporomandibular disorders (TMD) in patients that presented dentofacial deformities requiring orthognathic surgery.

MATERIAL AND METHODS

The sample comprised a total of 113 patients of both sexes. The diagnosis of TMD was performed before orthognathic surgery between Research Diagnostic Criteria for Temporomandibular Disorders (RDC-TMD). According to the TMD assessment, the patients were divided into 3 major groups: myofascial pain, articular disc displacements and other TMD conditions (arthralgia, arthritis, and arthrosis). Genomic DNA was collected from saliva samples and genetic polymorphisms in FGF3 (rs1893047 and rs7932320), FGF10 (rs900379) and FGF13 (rs5931572 and rs5974804) were analyzed by real-time polymerase chain reactions. The association between the TMD conditions and the genetic polymorphisms assessed were analyzed by Poisson Regression. The model was calculated on bivariate and adjusted by sex. The established alpha was 5%. Data were analyzed by using SPSS software (IBM, Armonk, NY).

RESULTS

The genetic polymorphisms rs7932320 in FGF3 (P < 0.001) and rs900379 in FGF10 (P < 0.05) were associated with the presence of muscle disorder. The genetic polymorphisms rs1893047 in FGF3, rs900379 in FGF10, and rs5974804 and rs5931572 in FGF13, were associated with the presence of disk displacement (P < 0.05). The genetic polymorphisms rs1893047 and rs7932320 in FGF3, rs900379 in FGF10, and rs900379 in FGF10 were associated with other TMD conditions (P < 0.05).

CONCLUSION

Genetic polymorphisms in FGF3, FGF10, and FGF13 genes were associated with temporomandibular disorders in a population with dentofacial deformities.

摘要

背景

评估成纤维细胞生长因子3（FGF3）、成纤维细胞生长因子10（FGF10）和成纤维细胞生长因子13（FGF13）基因多态性是否与需要正颌手术的牙颌面畸形患者的颞下颌关节紊乱病（TMD）相关。

材料与方法

样本共包括113例男女患者。在正颌手术前，根据颞下颌关节紊乱病研究诊断标准（RDC-TMD）对TMD进行诊断。根据TMD评估结果，将患者分为3个主要组：肌筋膜疼痛、关节盘移位和其他TMD情况（关节痛、关节炎和关节病）。从唾液样本中收集基因组DNA，并通过实时聚合酶链反应分析FGF3（rs1893047和rs7932320）、FGF10（rs900379）和FGF13（rs5931572和rs5974804）的基因多态性。通过泊松回归分析TMD情况与评估的基因多态性之间的关联。该模型在双变量基础上计算，并按性别进行校正。设定的α为5%。使用SPSS软件（IBM，纽约州阿蒙克）分析数据。

结果

FGF3中的基因多态性rs7932320（P<0.001）和FGF10中的rs900379（P<0.05）与肌肉疾病的存在相关。FGF3中的基因多态性rs1893047、FGF10中的rs900379以及FGF13中的rs5974804和rs5931572与关节盘移位的存在相关（P<0.05）。FGF3中的基因多态性rs1893047和rs7932320、FGF10中的rs900379以及FGF10中的rs900379与其他TMD情况相关（P<0.05）。