Cruz Diogo, Monteiro Francisca, Paço Maria, Vaz-Silva Manuel, Lemos Carolina, Alves-Ferreira Miguel, Pinho Teresa
School of Medicine, University of Minho, Braga, Portugal.
Center for Microelectromechanical Systems (CMEMS), University of Minho, Campus Azurém, 4800-058 Guimarães, Portugal.
Jpn Dent Sci Rev. 2022 Nov;58:69-88. doi: 10.1016/j.jdsr.2022.02.002. Epub 2022 Feb 23.
Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were and was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of gene regulation on either TMD or PHD was found. The most robust results are concerning the gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of and genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.
原发性头痛疾病（PHD），尤其是偏头痛，与颞下颌关节紊乱病（TMD）密切相关，二者存在一些口面部疼痛模式。这两种疾病都有已被研究的显著遗传因素。本系统评价遵循PRISMA指南进行，全面总结并讨论了TMD与PHD之间的遗传重叠，以辅助未来潜在治疗靶点的研究。本评价纳入了2015年至2020年间发表的8篇英文原创文章，这些文章与TMD和/或PHD相关。在PHD和TMD研究中同时评估的基因是 ，并且已证明其在TMD发病机制中起关键作用，因为所有研究都得出了其对疾病发生有影响的结论，尽管未发现其与PHD有关联。未发现 基因调控对TMD或PHD有影响的证据。最有力的结果与 基因有关，该基因存在于两种临床病症的基因图谱中。这项新的系统评价不仅强调了需要清楚了解 和 基因在疼痛发病机制中的作用，还评估了它们作为治疗这两种病症的有前景治疗靶点的潜力。
