Wang Jing, Bai Xiao-Gang, Liu Zhe
Department of Endocrine and Metabolism.
Department of Cardiology, Yan'an University Affiliated Hospital, Yan'an, China.
Medicine (Baltimore). 2019 Sep;98(39):e17286. doi: 10.1097/MD.0000000000017286.
This study aims to systematically investigate the impact of ultrasound angiography (UA) combined with fine needle aspiration (FNA) for the diagnosis of thyroid nodules (TNs).
The following electronic databases will be searched: MEDLINE, EMBASE, Cochrane Library, PsycINFO, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. We will search them from their inceptions to the present without language limitations. We will consider all case-controlled studies on investigating the impact of diagnosis UA combined FNA for TNs. We will apply Quality Assessment of Diagnostic Accuracy Studies tool to assess methodological quality for all eligible studies.
In this study, outcomes consist of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. All these outcomes will be analyzed to evaluate the diagnostic accuracy of UA combined with FNA for TNs.
This study will provide evidence of the diagnostic accuracy of UA combined with FNA for TNs.
PROSPERO CRD42019138884.
本研究旨在系统调查超声血管造影（UA）联合细针穿刺抽吸（FNA）对甲状腺结节（TNs）诊断的影响。
将检索以下电子数据库：MEDLINE、EMBASE、Cochrane图书馆、PsycINFO、科学网、护理及相关健康文献累积索引、补充与替代医学数据库、中国生物医学文献数据库和中国知网。我们将从各数据库建库起至目前进行检索，无语言限制。我们将纳入所有关于研究UA联合FNA对TNs诊断影响的病例对照研究。我们将应用诊断准确性研究质量评估工具来评估所有符合条件研究的方法学质量。
在本研究中，结局指标包括敏感性、特异性、阳性似然比、阴性似然比和诊断比值比。将对所有这些结局指标进行分析，以评估UA联合FNA对TNs的诊断准确性。
本研究将为UA联合FNA对TNs的诊断准确性提供证据。
PROSPERO CRD42019138884
