Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Italy.
CNS Spectr. 2020 Aug;25(4):527-534. doi: 10.1017/S109285291900138X. Epub 2019 Oct 2.
While the literature frequently highlighted an association between social anxiety disorder (SAD) and obsessive-compulsive disorder (OCD), few studies investigated the overlapping features of these conditions. The presented work evaluated the relationship between SAD and OCD spectrum in a clinical population and in healthy controls (HC).
Fifty-six patients with OCD, 51 with SAD, 43 with major depressive disorder (MDD), and 59 HC (N = 209) were assessed using the Mini International Neuropsychiatric Interview, the Social Phobia Spectrum (SCI-SHY), and the Obsessive-Compulsive Spectrum (SCI-OBS).
SAD patients scored significantly higher than other groups on all SCI-SHY domains and total score; OCD patients scored significantly higher than HC. MDD patients scored significantly higher than HC on the SCI-SHY total, Behavioral inhibition, and Interpersonal sensitivity domains. OCD patients scored significantly higher than other groups on all SCI-OBS domains except Doubt, for which OCD and SAD scored equally high. SAD patients scored significantly higher than HC on the SCI-OBS total, Childhood/adolescence, Doubt, and Hypercontrol domains. MDD patients scored significantly higher than HC on the Hypercontrol domain. SCI-OBS and SCI-SHY were widely correlated among groups, although lower correlations were found among OCD patients. Stronger correlations were observed between SCI-SHY Interpersonal sensitivity and SCI-OBS Doubt, Obsessive-compulsive themes, and Hypercontrol; between SCI-SHY Specific anxieties/phobic features and SCI-OBS Obsessive-compulsive themes; and between SCI-SHY Behavioral inhibition and SCI-OBS Doubt, with slightly different patterns among groups.
OCD and SAD spectrums widely overlap in clinical samples and in the general population. Interpersonal sensitivity and obsessive doubts might represent a common cognitive core for these conditions.
尽管文献经常强调社交焦虑障碍（SAD）和强迫症（OCD）之间存在关联，但很少有研究调查这些病症的重叠特征。本研究评估了临床人群和健康对照组（HC）中 SAD 和 OCD 谱系之间的关系。
56 例强迫症患者、51 例社交焦虑障碍患者、43 例重度抑郁症患者和 59 例健康对照组（共 209 例）接受了 Mini 国际神经精神访谈、社交恐惧症谱系（SCI-SHY）和强迫症谱系（SCI-OBS）评估。
SAD 患者在所有 SCI-SHY 领域和总分上的得分均显著高于其他组；强迫症患者的得分显著高于 HC。MDD 患者在 SCI-SHY 总分、行为抑制和人际敏感领域的得分显著高于 HC。除了怀疑，强迫症患者在所有 SCI-OBS 领域的得分均显著高于其他组，而 SAD 和强迫症的得分则相等。SAD 患者在 SCI-OBS 总分、儿童/青少年、怀疑和过度控制领域的得分显著高于 HC。MDD 患者在过度控制领域的得分显著高于 HC。SCI-OBS 和 SCI-SHY 在各群组之间广泛相关，但在强迫症患者中相关性较低。在 SAD 患者中，SCI-SHY 人际敏感与 SCI-OBS 怀疑、强迫主题和过度控制之间的相关性更强；SCI-SHY 特定焦虑/恐惧特征与 SCI-OBS 强迫主题之间的相关性更强；SCI-SHY 行为抑制与 SCI-OBS 怀疑之间的相关性更强，而各组之间的模式略有不同。
在临床样本和普通人群中，OCD 和 SAD 谱系广泛重叠。人际敏感和强迫性怀疑可能是这些病症的共同认知核心。
