当橡胶遇到路：适应性免疫细胞的固有特征如何在移植同种异体免疫中发挥关键作用。
When rubber meets the road: how innate features of adaptive immune cells play critical roles in transplant alloimmunity.
机构信息
Department of Surgery, Emory Transplant Center, Emory University, Atlanta, Georgia, USA.
出版信息
Curr Opin Organ Transplant. 2019 Dec;24(6):659-663. doi: 10.1097/MOT.0000000000000706.
PURPOSE OF REVIEW
Studies on adaptive cells have largely focused on features that are specific to adaptive immunity. However, adaptive cells utilize innate cell features to modulate their responses, and this area of T and B-cell biology is understudied. This review will highlight recent work done to understand how innate features of adaptive immune cells modulate alloimmunity.
RECENT FINDINGS
Over the past year, research has shown that T-cell-expressed danger-associated molecular patterns, Toll-like receptors, complement receptors, and Fc receptors regulate T-cell alloimmunity in a cell-intrinsic manner. Further, IL-17 and p40 of IL-12 have been implicated in the migration of T cells into allografts. Lastly, innate B cells, specifically B1 cells, have been shown to produce clinically relevant autoantibody associated with poor graft outcome.
SUMMARY
These data provide evidence that innate features are utilized by adaptive immune cells to control adaptive alloimmunity.
目的综述
关于适应性细胞的研究主要集中在适应性免疫特有的特征上。然而，适应性细胞利用先天细胞特征来调节其反应，而这一领域的 T 细胞和 B 细胞生物学尚未得到充分研究。本综述将重点介绍最近的研究工作，以了解适应性免疫细胞的先天特征如何调节同种异体免疫。
最近的发现
在过去的一年中，研究表明 T 细胞表达的危险相关分子模式、Toll 样受体、补体受体和 Fc 受体以细胞内固有方式调节 T 细胞同种异体免疫。此外，IL-17 和 IL-12 的 p40 已被牵连到 T 细胞向同种异体移植物的迁移中。最后，先天 B 细胞，特别是 B1 细胞，已被证明产生与不良移植物结果相关的临床相关自身抗体。
总结
这些数据提供了证据，表明适应性免疫细胞利用先天特征来控制适应性同种异体免疫。
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