United They Stand, Divided They Fall. 联合则存，分裂则亡。

United They Stand, Divided They Fall.

机构信息

Department of Biomedical Genetics and Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.

Department of Cell Biology and Ludwig Cancer Center, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Cell Metab. 2019 Oct 1;30(4):624-625. doi: 10.1016/j.cmet.2019.09.008.

DOI:10.1016/j.cmet.2019.09.008

PMID:31577930

Abstract

Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer oxidative stress.

摘要

在转移扩散过程中离开其自然环境的癌细胞，为了生存必须适应众多压力。在本期中，Labuschagne 等人（2019 年）强调了一种克服这些压力的适应性机制，即细胞聚集，它会诱导缺氧环境和代谢重编程，以缓冲氧化应激。